Intracellular DNA replication and differentiation of Trypanosoma cruzi is asynchronous within individual host cells in vivo at all stages of infection

Martin C. Taylor; Alexander Ward; Francisco Olmo; Shiromani Jayawardhana; Amanda F. Francisco; Michael D. Lewis; John M. Kelly

doi:10.1371/journal.pntd.0008007

Loading metrics

Open Access

Peer-reviewed

Research Article

Intracellular DNA replication and differentiation of Trypanosoma cruzi is asynchronous within individual host cells in vivo at all stages of infection

Martin C. Taylor ,

Contributed equally to this work with: Martin C. Taylor, Alexander Ward, Francisco Olmo, Shiromani Jayawardhana

Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: martin.taylor@lshtm.ac.uk

Affiliation Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom

http://orcid.org/0000-0003-4147-0693

⨯
Alexander Ward ,

Contributed equally to this work with: Martin C. Taylor, Alexander Ward, Francisco Olmo, Shiromani Jayawardhana

Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Affiliation Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Francisco Olmo ,

Contributed equally to this work with: Martin C. Taylor, Alexander Ward, Francisco Olmo, Shiromani Jayawardhana

Roles Funding acquisition, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Affiliation Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Shiromani Jayawardhana ,

Contributed equally to this work with: Martin C. Taylor, Alexander Ward, Francisco Olmo, Shiromani Jayawardhana

Roles Formal analysis, Investigation, Validation, Visualization, Writing – review & editing

Affiliation Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Amanda F. Francisco,

Roles Investigation, Writing – review & editing

Affiliation Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Michael D. Lewis,

Roles Funding acquisition, Investigation, Methodology, Writing – review & editing

Affiliation Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
John M. Kelly

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

Affiliation Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯

Intracellular DNA replication and differentiation of Trypanosoma cruzi is asynchronous within individual host cells in vivo at all stages of infection

Martin C. Taylor,
Alexander Ward,
Francisco Olmo,
Shiromani Jayawardhana,
Amanda F. Francisco,
Michael D. Lewis,
John M. Kelly

Published: March 20, 2020
https://doi.org/10.1371/journal.pntd.0008007

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Parasitic diseases
Is the Subject Area "Parasitic diseases" applicable to this article?

Thanks for your feedback.
Amastigotes
Is the Subject Area "Amastigotes" applicable to this article?

Thanks for your feedback.
Parasite replication
Is the Subject Area "Parasite replication" applicable to this article?

Thanks for your feedback.
DNA replication
Is the Subject Area "DNA replication" applicable to this article?

Thanks for your feedback.
Kinetoplasts
Is the Subject Area "Kinetoplasts" applicable to this article?

Thanks for your feedback.
Trypanosoma cruzi
Is the Subject Area "Trypanosoma cruzi" applicable to this article?

Thanks for your feedback.
Host cells
Is the Subject Area "Host cells" applicable to this article?

Thanks for your feedback.
Trypomastigotes
Is the Subject Area "Trypomastigotes" applicable to this article?

Thanks for your feedback.