Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymerase

Hideaki Shimizu; Akatsuki Saito; Junko Mikuni; Emi E. Nakayama; Hiroo Koyama; Teruki Honma; Mikako Shirouzu; Shun-ichi Sekine; Tatsuo Shioda

doi:10.1371/journal.pntd.0007894

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Open Access

Peer-reviewed

Research Article

Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymerase

Hideaki Shimizu ,

Contributed equally to this work with: Hideaki Shimizu, Akatsuki Saito

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliation RIKEN Center for Biosystems Dynamics Research, Suehiro-cho, Tsurumi-ku, Yokohama, Japan

http://orcid.org/0000-0003-0174-5947

⨯
Akatsuki Saito ,

Contributed equally to this work with: Hideaki Shimizu, Akatsuki Saito

Roles Conceptualization, Data curation, Formal analysis, Investigation, Visualization, Writing – original draft

Affiliation Research Institute for Microbial Diseases, Osaka University, Osaka, Japan

http://orcid.org/0000-0002-2792-4399

⨯
Junko Mikuni,

Roles Data curation, Investigation, Visualization

Affiliation RIKEN Center for Biosystems Dynamics Research, Suehiro-cho, Tsurumi-ku, Yokohama, Japan
⨯
Emi E. Nakayama,

Roles Conceptualization, Investigation, Visualization

Affiliation Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
⨯
Hiroo Koyama,

Roles Investigation, Methodology

Affiliation Drug Discovery Chemistry Platform Unit, RIKEN Center for Sustainable Resource Science, Hirosawa, Wako, Saitama, Japan
⨯
Teruki Honma,

Roles Investigation, Methodology, Visualization, Writing – review & editing

Affiliation RIKEN Center for Biosystems Dynamics Research, Suehiro-cho, Tsurumi-ku, Yokohama, Japan
⨯
Mikako Shirouzu,

Roles Supervision, Visualization, Writing – review & editing

Affiliation RIKEN Center for Biosystems Dynamics Research, Suehiro-cho, Tsurumi-ku, Yokohama, Japan
⨯
Shun-ichi Sekine ,

Roles Conceptualization, Funding acquisition, Investigation, Supervision, Visualization, Writing – review & editing

* E-mail: shunichi.sekine@riken.jp (SS); shioda@biken.osaka-u.ac.jp (TS)

Affiliation RIKEN Center for Biosystems Dynamics Research, Suehiro-cho, Tsurumi-ku, Yokohama, Japan
⨯
Tatsuo Shioda

Roles Conceptualization, Funding acquisition, Investigation, Supervision, Visualization, Writing – review & editing

* E-mail: shunichi.sekine@riken.jp (SS); shioda@biken.osaka-u.ac.jp (TS)

Affiliation Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
⨯

Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymerase

Hideaki Shimizu,
Akatsuki Saito,
Junko Mikuni,
Emi E. Nakayama,
Hiroo Koyama,
Teruki Honma,
Mikako Shirouzu,
Shun-ichi Sekine,
Tatsuo Shioda

Published: November 18, 2019
https://doi.org/10.1371/journal.pntd.0007894

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