A new human challenge model for testing heat-stable toxin-based vaccine candidates for enterotoxigenic Escherichia coli diarrhea – dose optimization, clinical outcomes, and CD4+ T cell responses

• Sunniva Todnem Sakkestad,

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Clinical Science, Faculty of Medicine, University of Bergen, Bergen, Norway

  http://orcid.org/0000-0002-6413-0432

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• Hans Steinsland,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Centre for Intervention Science in Maternal and Child Health (CISMAC), Centre for International Health, Department of Global Public Health and Primary Care, Faculty of Medicine, University of Bergen, Bergen, Norway, Department of Biomedicine, Faculty of Medicine, University of Bergen, Bergen, Norway

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• Steinar Skrede,

  Roles Conceptualization, Investigation, Writing – review & editing

  Affiliations Department of Clinical Science, Faculty of Medicine, University of Bergen, Bergen, Norway, Division for Infectious Diseases, Department of Medicine, Haukeland University Hospital, Bergen, Norway

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• Kristine Lillebø,

  Roles Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Microbiology, Haukeland University Hospital, Bergen, Norway

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• Dag Harald Skutlaberg,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliations Department of Clinical Science, Faculty of Medicine, University of Bergen, Bergen, Norway, Department of Microbiology, Haukeland University Hospital, Bergen, Norway

  http://orcid.org/0000-0003-3434-6715

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• Anne Berit Guttormsen,

  Roles Conceptualization, Investigation, Writing – review & editing

  Affiliations Department of Clinical Science, Faculty of Medicine, University of Bergen, Bergen, Norway, Department of Anesthesia and Intensive Care, Haukeland University Hospital, Bergen, Norway

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• Anton Zavialov,

  Roles Methodology, Writing – review & editing

  Affiliation Joint Biotechnology Laboratory, Department of Chemistry, University of Turku, Turku, Finland

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• Sari Paavilainen,

  Roles Methodology, Writing – review & editing

  Affiliation Joint Biotechnology Laboratory, Department of Chemistry, University of Turku, Turku, Finland

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• Hanne Søyland,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Division for Infectious Diseases, Department of Medicine, Haukeland University Hospital, Bergen, Norway

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• Marianne Sævik,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Division for Infectious Diseases, Department of Medicine, Haukeland University Hospital, Bergen, Norway

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• Astrid Rykkje Heien,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Division for Infectious Diseases, Department of Medicine, Haukeland University Hospital, Bergen, Norway

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• Marit Gjerde Tellevik,

  Roles Investigation, Writing – review & editing

  Affiliation Norwegian National Advisory Unit on Tropical Infectious Diseases, Department of Medicine, Haukeland University Hospital, Bergen, Norway

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• Eileen Barry,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliation Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, United States of America

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• Nina Langeland,

  Roles Conceptualization, Writing – review & editing

  Affiliations Department of Clinical Science, Faculty of Medicine, University of Bergen, Bergen, Norway, Norwegian National Advisory Unit on Tropical Infectious Diseases, Department of Medicine, Haukeland University Hospital, Bergen, Norway, Department of Medicine, Haraldsplass Deaconess Hospital, Bergen, Norway

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• Halvor Sommerfelt,

  Roles Conceptualization, Formal analysis, Methodology, Writing – review & editing

  Affiliations Centre for Intervention Science in Maternal and Child Health (CISMAC), Centre for International Health, Department of Global Public Health and Primary Care, Faculty of Medicine, University of Bergen, Bergen, Norway, Norwegian Institute of Public Health, Ministry of Health and Care Services, Oslo, Norway

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•  [ ... ],
• Kurt Hanevik

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Writing – review & editing

  * E-mail: Kurt.Hanevik@uib.no

  Affiliations Department of Clinical Science, Faculty of Medicine, University of Bergen, Bergen, Norway, Norwegian National Advisory Unit on Tropical Infectious Diseases, Department of Medicine, Haukeland University Hospital, Bergen, Norway

  http://orcid.org/0000-0002-1466-2326

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