High throughput screening and identification of coagulopathic snake venom proteins and peptides using nanofractionation and proteomics approaches

Julien Slagboom; Marija Mladić; Chunfang Xie; Taline D. Kazandjian; Freek Vonk; Govert W. Somsen; Nicholas R. Casewell; Jeroen Kool

doi:10.1371/journal.pntd.0007802

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Open Access

Peer-reviewed

Research Article

High throughput screening and identification of coagulopathic snake venom proteins and peptides using nanofractionation and proteomics approaches

Julien Slagboom,

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

Affiliations Division of BioAnalytical Chemistry, Amsterdam Institute for Molecules Medicines and Systems, VU University Amsterdam, Amsterdam, The Netherlands, Centre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
⨯
Marija Mladić,

Roles Formal analysis, Investigation, Methodology, Software, Writing – review & editing

Affiliation Animal Sciences and Health, Institute of Biology Leiden, Leiden University, Leiden, The Netherlands
⨯
Chunfang Xie,

Roles Data curation, Validation

Affiliation Division of BioAnalytical Chemistry, Amsterdam Institute for Molecules Medicines and Systems, VU University Amsterdam, Amsterdam, The Netherlands
⨯
Taline D. Kazandjian,

Roles Visualization

Affiliation Centre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
⨯
Freek Vonk,

Roles Resources, Writing – review & editing

Affiliation Naturalis Biodiversity Center, Leiden, The Netherlands
⨯
Govert W. Somsen,

Roles Project administration, Supervision, Writing – review & editing

Affiliation Division of BioAnalytical Chemistry, Amsterdam Institute for Molecules Medicines and Systems, VU University Amsterdam, Amsterdam, The Netherlands
⨯
Nicholas R. Casewell,

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

Affiliation Centre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
⨯
Jeroen Kool

Roles Conceptualization, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: j.kool@vu.nl

Affiliation Division of BioAnalytical Chemistry, Amsterdam Institute for Molecules Medicines and Systems, VU University Amsterdam, Amsterdam, The Netherlands

http://orcid.org/0000-0002-0011-5612

⨯

High throughput screening and identification of coagulopathic snake venom proteins and peptides using nanofractionation and proteomics approaches

Julien Slagboom,
Marija Mladić,
Chunfang Xie,
Taline D. Kazandjian,
Freek Vonk,
Govert W. Somsen,
Nicholas R. Casewell,
Jeroen Kool

Published: April 1, 2020
https://doi.org/10.1371/journal.pntd.0007802

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Venoms
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Toxins
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Snakes
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Snakebite
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Anticoagulants
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Blood plasma
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