Vaccination against the digestive enzyme Cathepsin B using a YS1646 Salmonella enterica Typhimurium vector provides almost complete protection against Schistosoma mansoni challenge in a mouse model

Adam S. Hassan; Nicholas H. Zelt; Dilhan J. Perera; Momar Ndao; Brian J. Ward

doi:10.1371/journal.pntd.0007490

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Open Access

Peer-reviewed

Research Article

Vaccination against the digestive enzyme Cathepsin B using a YS1646 Salmonella enterica Typhimurium vector provides almost complete protection against Schistosoma mansoni challenge in a mouse model

Adam S. Hassan,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliations Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada, Research Institute of the McGill University Health Centre (RI-MUHC), Montreal, Quebec, Canada
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Nicholas H. Zelt,

Roles Data curation, Methodology

Affiliations Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada, Research Institute of the McGill University Health Centre (RI-MUHC), Montreal, Quebec, Canada
⨯
Dilhan J. Perera,

Roles Methodology

Affiliations Research Institute of the McGill University Health Centre (RI-MUHC), Montreal, Quebec, Canada, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada
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Momar Ndao ,

Roles Conceptualization, Formal analysis, Investigation, Project administration, Resources, Supervision, Validation, Writing – review & editing

* E-mail: momar.ndao@mcgill.ca (MN); brian.ward@mcgill.ca (BJW)

Affiliations Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada, Research Institute of the McGill University Health Centre (RI-MUHC), Montreal, Quebec, Canada, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada

http://orcid.org/0000-0002-9012-4212

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Brian J. Ward

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: momar.ndao@mcgill.ca (MN); brian.ward@mcgill.ca (BJW)

Affiliations Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada, Research Institute of the McGill University Health Centre (RI-MUHC), Montreal, Quebec, Canada, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada
⨯

Vaccination against the digestive enzyme Cathepsin B using a YS1646 Salmonella enterica Typhimurium vector provides almost complete protection against Schistosoma mansoni challenge in a mouse model

Adam S. Hassan,
Nicholas H. Zelt,
Dilhan J. Perera,
Momar Ndao,
Brian J. Ward

Published: December 2, 2019
https://doi.org/10.1371/journal.pntd.0007490
See the preprint

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