A single-dose ChAdOx1-vectored vaccine provides complete protection against Nipah Bangladesh and Malaysia in Syrian golden hamsters

Neeltje van Doremalen; Teresa Lambe; Sarah Sebastian; Trenton Bushmaker; Robert Fischer; Friederike Feldmann; Elaine Haddock; Michael Letko; Victoria A. Avanzato; Ilona Rissanen; Rachel LaCasse; Dana Scott; Thomas A. Bowden; Sarah Gilbert; Vincent Munster

doi:10.1371/journal.pntd.0007462

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Open Access

Peer-reviewed

Research Article

A single-dose ChAdOx1-vectored vaccine provides complete protection against Nipah Bangladesh and Malaysia in Syrian golden hamsters

Neeltje van Doremalen ,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft

* E-mail: neeltje.vandoremalen@nih.gov (NvD); sarah.gilbert@ndm.ox.ac.uk (SG)

Affiliation Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, United States of America

http://orcid.org/0000-0003-4368-6359

⨯
Teresa Lambe,

Roles Conceptualization, Methodology, Writing – original draft

Affiliation The Jenner Institute, University of Oxford, Oxford, United Kingdom
⨯
Sarah Sebastian,

Roles Methodology

Affiliation The Jenner Institute, University of Oxford, Oxford, United Kingdom
⨯
Trenton Bushmaker,

Roles Methodology

Affiliation Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, United States of America
⨯
Robert Fischer,

Roles Methodology

Affiliation Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, United States of America
⨯
Friederike Feldmann,

Roles Methodology

Affiliation Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, United States of America
⨯
Elaine Haddock,

Roles Methodology

Affiliation Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, United States of America
⨯
Michael Letko,

Roles Methodology

Affiliation Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, United States of America
⨯
Victoria A. Avanzato,

Roles Methodology

Affiliations Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, United States of America, Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
⨯
Ilona Rissanen,

Roles Methodology

Affiliation Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
⨯
Rachel LaCasse,

Roles Methodology

Affiliation Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, United States of America
⨯
Dana Scott,

Roles Formal analysis, Methodology

Affiliation Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, United States of America
⨯
Thomas A. Bowden,

Roles Methodology

Affiliation Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

http://orcid.org/0000-0002-8066-8785

⨯
Sarah Gilbert ,

Roles Conceptualization, Writing – review & editing

* E-mail: neeltje.vandoremalen@nih.gov (NvD); sarah.gilbert@ndm.ox.ac.uk (SG)

Affiliation The Jenner Institute, University of Oxford, Oxford, United Kingdom

http://orcid.org/0000-0002-6823-9750

⨯
Vincent Munster

Roles Conceptualization, Writing – review & editing

Affiliation Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, United States of America

http://orcid.org/0000-0002-2288-3196

⨯

A single-dose ChAdOx1-vectored vaccine provides complete protection against Nipah Bangladesh and Malaysia in Syrian golden hamsters

Neeltje van Doremalen,
Teresa Lambe,
Sarah Sebastian,
Trenton Bushmaker,
Robert Fischer,
Friederike Feldmann,
Elaine Haddock,
Michael Letko,
Victoria A. Avanzato,
Ilona Rissanen

Published: June 6, 2019
https://doi.org/10.1371/journal.pntd.0007462

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Hamsters
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