Yellow fever virus is susceptible to sofosbuvir both in vitro and in vivo

Caroline S. de Freitas; Luiza M. Higa; Carolina Q. Sacramento; André C. Ferreira; Patrícia A. Reis; Rodrigo Delvecchio; Fabio L. Monteiro; Giselle Barbosa-Lima; Harrison James Westgarth; Yasmine Rangel Vieira; Mayara Mattos; Natasha Rocha; Lucas Villas Bôas Hoelz; Rennan Papaleo Paes Leme; Mônica M. Bastos; Gisele Olinto L. Rodrigues; Carla Elizabeth M. Lopes; Celso Martins Queiroz-Junior; Cristiano X. Lima; Vivian V. Costa; Mauro M. Teixeira; Fernando A. Bozza; Patrícia T. Bozza; Nubia Boechat; Amilcar Tanuri; Thiago Moreno L. Souza

doi:10.1371/journal.pntd.0007072

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Open Access

Peer-reviewed

Research Article

Yellow fever virus is susceptible to sofosbuvir both in vitro and in vivo

Caroline S. de Freitas ,

Contributed equally to this work with: Caroline S. de Freitas, Luiza M. Higa

Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil, National Institute for Science and Technology on Innovation on Neglected Diseases (INCT/IDN), Center for Technological Development in Health (CDTS), Fiocruz, Rio de Janeiro, RJ, Brazil
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Luiza M. Higa ,

Contributed equally to this work with: Caroline S. de Freitas, Luiza M. Higa

Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Laboratório de Virologia Molecular, Instituto de Biologia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil
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Carolina Q. Sacramento,

Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

Affiliations Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil, National Institute for Science and Technology on Innovation on Neglected Diseases (INCT/IDN), Center for Technological Development in Health (CDTS), Fiocruz, Rio de Janeiro, RJ, Brazil
⨯
André C. Ferreira,

Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

Affiliations Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil, National Institute for Science and Technology on Innovation on Neglected Diseases (INCT/IDN), Center for Technological Development in Health (CDTS), Fiocruz, Rio de Janeiro, RJ, Brazil
⨯
Patrícia A. Reis,

Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

Affiliation Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil
⨯
Rodrigo Delvecchio,

Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

Affiliation Laboratório de Virologia Molecular, Instituto de Biologia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil
⨯
Fabio L. Monteiro,

Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

Affiliation Laboratório de Virologia Molecular, Instituto de Biologia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil
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Giselle Barbosa-Lima,

Roles Formal analysis, Investigation, Methodology

Affiliation Instituto Nacional de Infectologia (INI), Fiocruz, Rio de Janeiro, RJ, Brazil
⨯
Harrison James Westgarth,

Roles Formal analysis, Methodology, Writing – review & editing

Affiliation Laboratório de Virologia Molecular, Instituto de Biologia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil
⨯
Yasmine Rangel Vieira,

Roles Formal analysis, Investigation, Methodology

Affiliations National Institute for Science and Technology on Innovation on Neglected Diseases (INCT/IDN), Center for Technological Development in Health (CDTS), Fiocruz, Rio de Janeiro, RJ, Brazil, Instituto Nacional de Infectologia (INI), Fiocruz, Rio de Janeiro, RJ, Brazil
⨯
Mayara Mattos,

Roles Investigation, Methodology

Affiliations Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil, National Institute for Science and Technology on Innovation on Neglected Diseases (INCT/IDN), Center for Technological Development in Health (CDTS), Fiocruz, Rio de Janeiro, RJ, Brazil
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Natasha Rocha,

Roles Formal analysis, Methodology

Affiliations Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil, National Institute for Science and Technology on Innovation on Neglected Diseases (INCT/IDN), Center for Technological Development in Health (CDTS), Fiocruz, Rio de Janeiro, RJ, Brazil
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Lucas Villas Bôas Hoelz,

Roles Formal analysis, Investigation, Methodology

Affiliation Instituto de Tecnologia de Fármacos (Farmanguinhos), Fiocruz, Rio de Janeiro, RJ, Brazil
⨯
Rennan Papaleo Paes Leme,

Roles Formal analysis, Investigation, Methodology

Affiliation Instituto de Tecnologia de Fármacos (Farmanguinhos), Fiocruz, Rio de Janeiro, RJ, Brazil
⨯
Mônica M. Bastos,

Roles Formal analysis, Visualization, Writing – original draft

Affiliation Instituto de Tecnologia de Fármacos (Farmanguinhos), Fiocruz, Rio de Janeiro, RJ, Brazil
⨯
Gisele Olinto L. Rodrigues,

Roles Formal analysis, Investigation, Methodology

Affiliations Center for Research and Development of Pharmaceuticals, Institute of Biological Sciences (ICB), Universidade Federal de Minas Gerais (UFMG), Minas Gerais, Brazil, Research Group in Arboviral Diseases, Department of Morphology, Institute of Biological Sciences (ICB), Universidade Federal de Minas Gerais (UFMG), Minas Gerais, Brazil
⨯
Carla Elizabeth M. Lopes,

Roles Formal analysis, Investigation, Methodology

Affiliations Center for Research and Development of Pharmaceuticals, Institute of Biological Sciences (ICB), Universidade Federal de Minas Gerais (UFMG), Minas Gerais, Brazil, Research Group in Arboviral Diseases, Department of Morphology, Institute of Biological Sciences (ICB), Universidade Federal de Minas Gerais (UFMG), Minas Gerais, Brazil

http://orcid.org/0000-0002-0529-1404

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Celso Martins Queiroz-Junior,

Roles Formal analysis, Investigation, Methodology

Affiliation Cardiac Lab, Department of Morphology, Institute of Biological Sciences (ICB), Universidade Federal de Minas Gerais (UFMG), Minas Gerais, Brazil
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Cristiano X. Lima,

Roles Formal analysis, Investigation, Methodology

Affiliation Departamento de Cirurgia, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
⨯
Vivian V. Costa,

Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

Affiliations Center for Research and Development of Pharmaceuticals, Institute of Biological Sciences (ICB), Universidade Federal de Minas Gerais (UFMG), Minas Gerais, Brazil, Research Group in Arboviral Diseases, Department of Morphology, Institute of Biological Sciences (ICB), Universidade Federal de Minas Gerais (UFMG), Minas Gerais, Brazil
⨯
Mauro M. Teixeira,

Roles Formal analysis, Funding acquisition, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Center for Research and Development of Pharmaceuticals, Institute of Biological Sciences (ICB), Universidade Federal de Minas Gerais (UFMG), Minas Gerais, Brazil, Immunopharmacology Lab, Department of Biochemistry and Immunology, Institute of Biological Sciences (ICB), Universidade Federal de Minas Gerais (UFMG), Minas Gerais, Brazil
⨯
Fernando A. Bozza,

Roles Formal analysis, Visualization, Writing – original draft, Writing – review & editing

Affiliations Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil, Instituto Nacional de Infectologia (INI), Fiocruz, Rio de Janeiro, RJ, Brazil
⨯
Patrícia T. Bozza,

Roles Formal analysis, Visualization, Writing – original draft, Writing – review & editing

Affiliation Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil

http://orcid.org/0000-0001-8349-9529

⨯
Nubia Boechat,

Roles Formal analysis, Visualization, Writing – original draft, Writing – review & editing

Affiliation Instituto de Tecnologia de Fármacos (Farmanguinhos), Fiocruz, Rio de Janeiro, RJ, Brazil
⨯
Amilcar Tanuri,

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft

Affiliation Laboratório de Virologia Molecular, Instituto de Biologia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil
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[ ... ],
Thiago Moreno L. Souza

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: tmoreno@cdts.fiocruz.br

Affiliations Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil, National Institute for Science and Technology on Innovation on Neglected Diseases (INCT/IDN), Center for Technological Development in Health (CDTS), Fiocruz, Rio de Janeiro, RJ, Brazil, Instituto Nacional de Infectologia (INI), Fiocruz, Rio de Janeiro, RJ, Brazil

http://orcid.org/0000-0003-2212-3899

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Yellow fever virus is susceptible to sofosbuvir both in vitro and in vivo

Caroline S. de Freitas,
Luiza M. Higa,
Carolina Q. Sacramento,
André C. Ferreira,
Patrícia A. Reis,
Rodrigo Delvecchio,
Fabio L. Monteiro,
Giselle Barbosa-Lima,
Harrison James Westgarth,
Yasmine Rangel Vieira

Published: January 30, 2019
https://doi.org/10.1371/journal.pntd.0007072

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