Nanoparticle delivery of a tetravalent E protein subunit vaccine induces balanced, type-specific neutralizing antibodies to each dengue virus serotype

• Stefan W. Metz,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, Chapel Hill, NC, United States of America

  http://orcid.org/0000-0002-9249-2844

  ⨯
• Ashlie Thomas,

  Roles Data curation

  Affiliation Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, Chapel Hill, NC, United States of America

  ⨯
• Alex Brackbill,

  Roles Data curation

  Affiliation Department of Pharmacology, University of North Carolina, Chapel Hill, Chapel Hill, NC, United States of America

  ⨯
• Yi Xianwen,

  Roles Data curation

  Affiliation Lineberger Comprehensive Center, University of North Carolina, Chapel Hill, Chapel Hill, NC, United States of America

  ⨯
• Michele Stone,

  Roles Resources

  Affiliation Liquidia Technologies, Research Triangle Park, Durham, NC, United States of America

  ⨯
• Katie Horvath,

  Roles Resources

  Affiliation Liquidia Technologies, Research Triangle Park, Durham, NC, United States of America

  ⨯
• Michael J. Miley,

  Roles Conceptualization, Methodology, Resources, Writing – review & editing

  Affiliation Department of Pharmacology, University of North Carolina, Chapel Hill, Chapel Hill, NC, United States of America

  ⨯
• Chris Luft,

  Roles Conceptualization, Methodology

  Affiliation Liquidia Technologies, Research Triangle Park, Durham, NC, United States of America

  ⨯
• Joseph M. DeSimone,

  Roles Conceptualization, Funding acquisition

  Affiliations Liquidia Technologies, Research Triangle Park, Durham, NC, United States of America, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, Chapel Hill, NC, United States of America, Department of Chemistry, University of North Carolina, Chapel Hill, Chapel Hill, NC, United States of America

  ⨯
• Shaomin Tian ,

  Roles Conceptualization, Data curation, Investigation, Methodology, Resources, Writing – original draft, Writing – review & editing

  * E-mail: shaomin_tian@med.unc.edu (ST); aravinda_desilva@med.unc.edu (AMdS)

  Affiliation Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, Chapel Hill, NC, United States of America

  ⨯
• Aravinda M. de Silva

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: shaomin_tian@med.unc.edu (ST); aravinda_desilva@med.unc.edu (AMdS)

  Affiliation Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, Chapel Hill, NC, United States of America

  ⨯