SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties

• Adrian Leontovyč,

  Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

  Affiliations Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Prague, Czech Republic, First Faculty of Medicine, Charles University, Prague, Czech Republic

  ⨯
• Lenka Ulrychová,

  Roles Formal analysis, Investigation, Methodology

  Affiliations Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Prague, Czech Republic, Department of Parasitology, Faculty of Science, Charles University, Prague, Czech Republic

  ⨯
• Anthony J. O’Donoghue,

  Roles Data curation, Formal analysis, Funding acquisition, Methodology, Resources, Writing – review & editing

  Affiliation Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, United States of America

  ⨯
• Jiří Vondrášek,

  Roles Formal analysis, Methodology, Software

  Affiliation Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Prague, Czech Republic

  ⨯
• Lucie Marešová,

  Roles Formal analysis, Methodology

  Affiliation Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Prague, Czech Republic

  ⨯
• Martin Hubálek,

  Roles Data curation, Methodology

  Affiliation Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Prague, Czech Republic

  ⨯
• Pavla Fajtová,

  Roles Formal analysis, Investigation

  Affiliations Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Prague, Czech Republic, First Faculty of Medicine, Charles University, Prague, Czech Republic

  ⨯
• Marta Chanová,

  Roles Conceptualization, Funding acquisition, Methodology, Resources, Writing – review & editing

  Affiliation Institute of Immunology and Microbiology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic

  http://orcid.org/0000-0003-2191-842X

  ⨯
• Zhenze Jiang,

  Roles Formal analysis

  Affiliation Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, United States of America

  ⨯
• Charles S. Craik,

  Roles Methodology, Resources, Writing – review & editing

  Affiliation Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, United States of America

  ⨯
• Conor R. Caffrey,

  Roles Conceptualization, Data curation, Funding acquisition, Methodology, Resources, Supervision, Writing – review & editing

  Affiliation Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, United States of America

  ⨯
• Michael Mareš,

  Roles Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  Affiliation Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Prague, Czech Republic

  ⨯
• Jan Dvořák ,

  Contributed equally to this work with: Jan Dvořák, Martin Horn

  Roles Conceptualization, Data curation, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing

  * E-mail: horn@uochb.cas.cz (MH); Dvorak19@af.czu.cz (JD)

  Affiliations Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Prague, Czech Republic, Department of Zoology and Fisheries, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Prague, Czech Republic

  ⨯
• Martin Horn

  Contributed equally to this work with: Jan Dvořák, Martin Horn

  Roles Conceptualization, Data curation, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – review & editing

  * E-mail: horn@uochb.cas.cz (MH); Dvorak19@af.czu.cz (JD)

  Affiliation Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Prague, Czech Republic

  http://orcid.org/0000-0001-9110-2018

  ⨯