Hepatitis B and hepatitis D virus infections in the Central African Republic, twenty-five years after a fulminant hepatitis outbreak, indicate continuing spread in asymptomatic young adults

Narcisse Patrice Komas; Sumantra Ghosh; Mariama Abdou-Chekaraou; Pierre Pradat; Nasser Al Hawajri; Alexandre Manirakiza; Gina Laure Laghoe; Claudine Bekondi; Ségolène Brichler; Jean-Omer Ouavéné; Abdoulaye Sépou; Brice Martial Yambiyo; Jean Chrysostome Gody; Valentin Fikouma; Athénais Gerber; Natali Abeywickrama Samarakoon; Dulce Alfaiate; Caroline Scholtès; Nora Martel; Frédéric Le Gal; Hugo Lo Pinto; Ikram Amri; Olivier Hantz; David Durantel; Jean-Louis Lesbordes; Emmanuel Gordien; Philippe Merle; Tudor Drugan; Christian Trépo; Fabien Zoulim; Jean-Claude Cortay; Alan Campbell Kay; Paul Dény

doi:10.1371/journal.pntd.0006377

Loading metrics

Open Access

Peer-reviewed

Research Article

Hepatitis B and hepatitis D virus infections in the Central African Republic, twenty-five years after a fulminant hepatitis outbreak, indicate continuing spread in asymptomatic young adults

Narcisse Patrice Komas ,

Contributed equally to this work with: Narcisse Patrice Komas, Paul Dény

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: npkomas@yahoo.fr (NPK); paul.deny@inserm.fr (PD)

Affiliation Laboratoire des hépatites virales, Institut Pasteur de Bangui, Bangui, Central African Republic
⨯
Sumantra Ghosh,

Roles Data curation, Formal analysis, Investigation, Software, Supervision, Validation, Writing – original draft

Affiliation INSERM, U1052, UMR CNRS 5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France
⨯
Mariama Abdou-Chekaraou,

Roles Formal analysis, Investigation, Software, Supervision, Validation, Writing – original draft

Affiliations INSERM, U1052, UMR CNRS 5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France, Service de Microbiologie Clinique, Hôpital Avicenne, Groupe des Hôpitaux Universitaires Paris Seine Saint-Denis, Assistance Publique–Hôpitaux de Paris, Bobigny, France, Université Paris 13/Sorbonne Paris Cité, UFR Santé Médecine Biologie Humaine, Bobigny, France
⨯
Pierre Pradat,

Roles Data curation, Formal analysis, Methodology, Software, Supervision, Validation, Writing – original draft

Affiliations INSERM, U1052, UMR CNRS 5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France, Center for Clinical Research, Croix-Rousse Hospital, Lyon, France, Hospices Civils de Lyon, Lyon, France/Université de Lyon I, Lyon, France
⨯
Nasser Al Hawajri,

Roles Data curation, Formal analysis, Methodology, Software, Validation

Affiliation Agence de Biomédecine, Saint Denis, France
⨯
Alexandre Manirakiza,

Roles Data curation, Investigation, Software, Validation, Writing – original draft

Affiliation Service d’Épidémiologie, Institut Pasteur de Bangui, Bangui, Central African Republic
⨯
Gina Laure Laghoe,

Roles Formal analysis, Investigation, Validation

Affiliation Laboratoire des hépatites virales, Institut Pasteur de Bangui, Bangui, Central African Republic
⨯
Claudine Bekondi,

Roles Investigation, Methodology, Resources, Supervision, Validation

Affiliation Laboratoire des hépatites virales, Institut Pasteur de Bangui, Bangui, Central African Republic
⨯
Ségolène Brichler,

Roles Investigation, Software, Supervision, Validation

Affiliation Service de Microbiologie Clinique, Hôpital Avicenne, Groupe des Hôpitaux Universitaires Paris Seine Saint-Denis, Assistance Publique–Hôpitaux de Paris, Bobigny, France, Université Paris 13/Sorbonne Paris Cité, UFR Santé Médecine Biologie Humaine, Bobigny, France
⨯
Jean-Omer Ouavéné †,

† Deceased.

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Resources, Visualization

Affiliation Service de Médecine Interne, Hôpital de l’Amitié, Avenue Indépendance, Bangui, Central African Republic
⨯
Abdoulaye Sépou,

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Supervision

Affiliation Service de Gynécologie Obstétrique, Hôpital Communautaire de Bangui, Avenue des Martyrs, Bangui, Central African Republic
⨯
Brice Martial Yambiyo,

Roles Data curation, Investigation, Methodology, Software

Affiliation Service d’Épidémiologie, Institut Pasteur de Bangui, Bangui, Central African Republic
⨯
Jean Chrysostome Gody,

Roles Conceptualization, Funding acquisition, Investigation, Resources, Writing – original draft

Affiliation Complexe Pédiatrique de Bangui, Bangui, Central African Republic
⨯
Valentin Fikouma,

Roles Conceptualization, Investigation, Resources, Validation, Writing – original draft

Affiliation Centre de Traitement Ambulatoire de l’Hôpital Communautaire de Bangui, Bangui, Central African Republic
⨯
Athénais Gerber,

Roles Investigation, Resources, Software, Validation

Affiliation Service de Microbiologie Clinique, Hôpital Avicenne, Groupe des Hôpitaux Universitaires Paris Seine Saint-Denis, Assistance Publique–Hôpitaux de Paris, Bobigny, France, Université Paris 13/Sorbonne Paris Cité, UFR Santé Médecine Biologie Humaine, Bobigny, France
⨯
Natali Abeywickrama Samarakoon,

Roles Formal analysis, Investigation, Software, Supervision, Validation

Affiliation INSERM, U1052, UMR CNRS 5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France
⨯
Dulce Alfaiate,

Roles Formal analysis, Investigation, Software, Validation, Writing – original draft

Affiliation INSERM, U1052, UMR CNRS 5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France
⨯
Caroline Scholtès,

Roles Formal analysis, Investigation, Methodology, Software, Validation

Affiliations INSERM, U1052, UMR CNRS 5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France, Hospices Civils de Lyon, Lyon, France/Université de Lyon I, Lyon, France, Laboratoire de Virologie, Croix-Rousse Hospital, Lyon, France
⨯
Nora Martel,

Roles Investigation, Software, Validation

Affiliation INSERM, U1052, UMR CNRS 5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France
⨯
Frédéric Le Gal,

Roles Formal analysis, Investigation, Supervision, Validation

Affiliation Service de Microbiologie Clinique, Hôpital Avicenne, Groupe des Hôpitaux Universitaires Paris Seine Saint-Denis, Assistance Publique–Hôpitaux de Paris, Bobigny, France, Université Paris 13/Sorbonne Paris Cité, UFR Santé Médecine Biologie Humaine, Bobigny, France
⨯
Hugo Lo Pinto,

Roles Investigation, Validation

Affiliation INSERM, U1052, UMR CNRS 5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France
⨯
Ikram Amri,

Roles Data curation, Investigation, Validation

Affiliation INSERM, U1052, UMR CNRS 5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France
⨯
Olivier Hantz,

Roles Conceptualization, Funding acquisition, Investigation, Resources, Validation

Affiliation INSERM, U1052, UMR CNRS 5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France
⨯
David Durantel,

Roles Investigation, Resources, Supervision

Affiliation INSERM, U1052, UMR CNRS 5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France
⨯
Jean-Louis Lesbordes,

Roles Investigation, Resources, Visualization

Affiliation INSERM, U1052, UMR CNRS 5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France
⨯
Emmanuel Gordien,

Roles Conceptualization, Funding acquisition, Supervision

Affiliation Service de Microbiologie Clinique, Hôpital Avicenne, Groupe des Hôpitaux Universitaires Paris Seine Saint-Denis, Assistance Publique–Hôpitaux de Paris, Bobigny, France, Université Paris 13/Sorbonne Paris Cité, UFR Santé Médecine Biologie Humaine, Bobigny, France
⨯
Philippe Merle,

Roles Funding acquisition, Supervision, Validation

Affiliations INSERM, U1052, UMR CNRS 5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France, Hospices Civils de Lyon, Lyon, France/Université de Lyon I, Lyon, France
⨯
Tudor Drugan,

Roles Data curation, Resources, Software, Validation

Affiliation Department of Medical Informatics and Biostatistics, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania

http://orcid.org/0000-0003-0097-262X

⨯
Christian Trépo,

Roles Conceptualization, Formal analysis, Funding acquisition, Resources, Supervision, Writing – original draft

Affiliations INSERM, U1052, UMR CNRS 5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France, Hospices Civils de Lyon, Lyon, France/Université de Lyon I, Lyon, France
⨯
Fabien Zoulim,

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Writing – original draft, Writing – review & editing

Affiliations INSERM, U1052, UMR CNRS 5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France, Hospices Civils de Lyon, Lyon, France/Université de Lyon I, Lyon, France
⨯
Jean-Claude Cortay,

Roles Funding acquisition, Methodology, Resources, Supervision, Writing – original draft

Affiliation INSERM, U1052, UMR CNRS 5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France
⨯
Alan Campbell Kay,

Roles Conceptualization, Data curation, Funding acquisition, Resources, Validation, Writing – original draft, Writing – review & editing

Affiliation INSERM, U1052, UMR CNRS 5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France
⨯
[ ... ],
Paul Dény

Contributed equally to this work with: Narcisse Patrice Komas, Paul Dény

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: npkomas@yahoo.fr (NPK); paul.deny@inserm.fr (PD)

Affiliations INSERM, U1052, UMR CNRS 5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France, Service de Microbiologie Clinique, Hôpital Avicenne, Groupe des Hôpitaux Universitaires Paris Seine Saint-Denis, Assistance Publique–Hôpitaux de Paris, Bobigny, France, Université Paris 13/Sorbonne Paris Cité, UFR Santé Médecine Biologie Humaine, Bobigny, France

http://orcid.org/0000-0003-1388-1049

⨯
[ view all ]
[ view less ]

Hepatitis B and hepatitis D virus infections in the Central African Republic, twenty-five years after a fulminant hepatitis outbreak, indicate continuing spread in asymptomatic young adults

Narcisse Patrice Komas,
Sumantra Ghosh,
Mariama Abdou-Chekaraou,
Pierre Pradat,
Nasser Al Hawajri,
Alexandre Manirakiza,
Gina Laure Laghoe,
Claudine Bekondi,
Ségolène Brichler,
Jean-Omer Ouavéné

Published: April 26, 2018
https://doi.org/10.1371/journal.pntd.0006377

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Hepatitis delta virus
Is the Subject Area "Hepatitis delta virus" applicable to this article?

Thanks for your feedback.
Hepatitis B virus
Is the Subject Area "Hepatitis B virus" applicable to this article?

Thanks for your feedback.
Medical risk factors
Is the Subject Area "Medical risk factors" applicable to this article?

Thanks for your feedback.
Liver disease and pregnancy
Is the Subject Area "Liver disease and pregnancy" applicable to this article?

Thanks for your feedback.
Epidemiology
Is the Subject Area "Epidemiology" applicable to this article?

Thanks for your feedback.
Blood
Is the Subject Area "Blood" applicable to this article?

Thanks for your feedback.
Phylogenetic analysis
Is the Subject Area "Phylogenetic analysis" applicable to this article?

Thanks for your feedback.
Vaccination and immunization
Is the Subject Area "Vaccination and immunization" applicable to this article?

Thanks for your feedback.