Comprehensive analysis of clinical Burkholderia pseudomallei isolates demonstrates conservation of unique lipid A structure and TLR4-dependent innate immune activation

• Sineenart Sengyee,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

  ⨯
• Sung Hwan Yoon,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Department of Microbial Pathogenesis, University of Maryland, Baltimore, MD, United States of America

  http://orcid.org/0000-0001-5794-3286

  ⨯
• Suporn Paksanont,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

  ⨯
• Thatcha Yimthin,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

  ⨯
• Vanaporn Wuthiekanun,

  Roles Resources, Writing – review & editing

  Affiliation Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

  http://orcid.org/0000-0002-3074-0742

  ⨯
• Direk Limmathurotsakul,

  Roles Resources, Writing – review & editing

  Affiliations Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

  http://orcid.org/0000-0001-7240-5320

  ⨯
• T. Eoin West,

  Roles Conceptualization, Supervision, Writing – review & editing

  Affiliations Division of Pulmonary and Critical Care Medicine, Harborview Medical Center, University of Washington, Seattle, WA, United States of America, International Respiratory and Severe Illness Center, University of Washington, Seattle, WA, United States of America

  ⨯
• Robert K. Ernst,

  Roles Conceptualization, Methodology, Resources, Supervision, Validation, Writing – review & editing

  Affiliation Department of Microbial Pathogenesis, University of Maryland, Baltimore, MD, United States of America

  ⨯
• Narisara Chantratita

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: narisara@tropmedres.ac

  Affiliations Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

  http://orcid.org/0000-0003-3906-7379

  ⨯