The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: A case series

Ravi Mehta; Cristiane Nascimento Soares; Raquel Medialdea-Carrera; Mark Ellul; Marcus Tulius Texeira da Silva; Anna Rosala-Hallas; Marcia Rodrigues Jardim; Girvan Burnside; Luciana Pamplona; Maneesh Bhojak; Radhika Manohar; Gabriel Amorelli Medeiros da Silva; Marcus Vinicius Adriano; Patricia Brasil; Rita Maria Ribeiro Nogueira; Carolina Cardoso Dos Santos; Lance Turtle; Patricia Carvalho de Sequeira; David W. Brown; Michael J. Griffiths; Ana Maria Bispo de Filippis; Tom Solomon

doi:10.1371/journal.pntd.0006212

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Peer-reviewed

Research Article

The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: A case series

Ravi Mehta ,

Contributed equally to this work with: Ravi Mehta, Cristiane Nascimento Soares, Raquel Medialdea-Carrera

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Writing – original draft, Writing – review & editing

* E-mail: tsolomon@liverpool.ac.uk (TS); Ravi.mehta@liverpool.ac.uk (RM)

Affiliations National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections, University of Liverpool, Liverpool, United Kingdom, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom
⨯
Cristiane Nascimento Soares ,

Contributed equally to this work with: Ravi Mehta, Cristiane Nascimento Soares, Raquel Medialdea-Carrera

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Writing – review & editing

Affiliation Department of Neurology, Hospital Federal dos Servidores do Estado, Rio de Janeiro, Brazil
⨯
Raquel Medialdea-Carrera ,

Contributed equally to this work with: Ravi Mehta, Cristiane Nascimento Soares, Raquel Medialdea-Carrera

Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Writing – original draft, Writing – review & editing

Affiliations National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections, University of Liverpool, Liverpool, United Kingdom, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom
⨯
Mark Ellul,

Roles Conceptualization, Methodology, Supervision, Writing – review & editing

Affiliations National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections, University of Liverpool, Liverpool, United Kingdom, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom, Department of Neurology, Walton Centre NHS Foundation Trust, Liverpool, United Kingdom

http://orcid.org/0000-0002-6115-8245

⨯
Marcus Tulius Texeira da Silva,

Roles Conceptualization, Data curation, Investigation, Resources

Affiliations Laboratório de Pesquisa em Neuroinfecção, Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, Brazil, Department of Neurology, Hospital de Clínicas de Niterói, Niterói, Brazil
⨯
Anna Rosala-Hallas,

Roles Formal analysis

Affiliation Department of Biostatistics, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom
⨯
Marcia Rodrigues Jardim,

Roles Data curation, Formal analysis, Investigation, Resources

Affiliation Department of Neurology, Hospital Universitário Pedro Ernesto, Rio de Janeiro, Brazil
⨯
Girvan Burnside,

Roles Formal analysis

Affiliation Department of Biostatistics, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom
⨯
Luciana Pamplona,

Roles Data curation, Investigation, Resources

Affiliation Department of Neurology, Hospital Geral de Bonsucesso, Rio de Janeiro, Brazil
⨯
Maneesh Bhojak,

Roles Formal analysis

Affiliation Department of Neurology, Walton Centre NHS Foundation Trust, Liverpool, United Kingdom
⨯
Radhika Manohar,

Roles Formal analysis

Affiliation Department of Neurology, Walton Centre NHS Foundation Trust, Liverpool, United Kingdom
⨯
Gabriel Amorelli Medeiros da Silva,

Roles Data curation, Investigation

Affiliation Department of Neurology, Hospital Federal dos Servidores do Estado, Rio de Janeiro, Brazil
⨯
Marcus Vinicius Adriano,

Roles Data curation, Investigation

Affiliation Department of Neurology, Hospital Barra D'or, Rio de Janeiro, Brazil
⨯
Patricia Brasil,

Roles Data curation, Investigation

Affiliation Laboratório de Pesquisa Clínica em Doenças Febris Agudas, Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, Brazil
⨯
Rita Maria Ribeiro Nogueira,

Roles Project administration, Writing – review & editing

Affiliation Flavivirus Reference Laboratory, Oswaldo Cruz Institute, Rio de Janeiro, Brazil
⨯
Carolina Cardoso Dos Santos,

Roles Data curation

Affiliation Flavivirus Reference Laboratory, Oswaldo Cruz Institute, Rio de Janeiro, Brazil
⨯
Lance Turtle,

Roles Conceptualization, Methodology, Writing – review & editing

Affiliations National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections, University of Liverpool, Liverpool, United Kingdom, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom, Department of Neurology, Walton Centre NHS Foundation Trust, Liverpool, United Kingdom
⨯
Patricia Carvalho de Sequeira,

Roles Conceptualization, Project administration, Resources

Affiliation Flavivirus Reference Laboratory, Oswaldo Cruz Institute, Rio de Janeiro, Brazil
⨯
David W. Brown,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Resources, Supervision, Writing – review & editing

Affiliations Influenza Reference Laboratory, Oswaldo Cruz Institute, Rio de Janeiro, Brazil, Virus Reference Department, National Infection Service, Public Health England, London, United Kingdom
⨯
Michael J. Griffiths,

Roles Conceptualization, Methodology, Supervision, Writing – review & editing

Affiliations National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections, University of Liverpool, Liverpool, United Kingdom, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom, Department of Neurology, Alder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom
⨯
Ana Maria Bispo de Filippis,

Roles Conceptualization, Formal analysis, Methodology, Supervision, Writing – review & editing

Affiliation Flavivirus Reference Laboratory, Oswaldo Cruz Institute, Rio de Janeiro, Brazil
⨯
[ ... ],
Tom Solomon

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: tsolomon@liverpool.ac.uk (TS); Ravi.mehta@liverpool.ac.uk (RM)

Affiliations National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections, University of Liverpool, Liverpool, United Kingdom, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom, Department of Neurology, Walton Centre NHS Foundation Trust, Liverpool, United Kingdom

http://orcid.org/0000-0001-7266-6547

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The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: A case series

Ravi Mehta,
Cristiane Nascimento Soares,
Raquel Medialdea-Carrera,
Mark Ellul,
Marcus Tulius Texeira da Silva,
Anna Rosala-Hallas,
Marcia Rodrigues Jardim,
Girvan Burnside,
Luciana Pamplona,
Maneesh Bhojak

Published: February 12, 2018
https://doi.org/10.1371/journal.pntd.0006212

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