Neutralization of antibody-enhanced dengue infection by VIS513, a pan serotype reactive monoclonal antibody targeting domain III of the dengue E protein

Yadunanda Budigi; Eugenia Z. Ong; Luke N. Robinson; Li Ching Ong; Kirk J. Rowley; Alexander Winnett; Hwee Cheng Tan; Sven Hobbie; Zachary Shriver; Gregory J. Babcock; Sylvie Alonso; Eng Eong Ooi

doi:10.1371/journal.pntd.0006209

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Open Access

Peer-reviewed

Research Article

Neutralization of antibody-enhanced dengue infection by VIS513, a pan serotype reactive monoclonal antibody targeting domain III of the dengue E protein

Yadunanda Budigi ,

Contributed equally to this work with: Yadunanda Budigi, Eugenia Z. Ong

Roles Conceptualization, Data curation, Formal analysis, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: yadunanda@smart.mit.edu (YB); eugenia.ong@duke-nus.edu.sg (EZO)

Affiliations Visterra Singapore International Pte Ltd, Singapore, Singapore, Infectious Diseases Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology, Singapore, Singapore
⨯
Eugenia Z. Ong ,

Contributed equally to this work with: Yadunanda Budigi, Eugenia Z. Ong

Roles Conceptualization, Data curation, Formal analysis, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: yadunanda@smart.mit.edu (YB); eugenia.ong@duke-nus.edu.sg (EZO)

Affiliations Experimental Therapeutics Centre, Agency for Science, Technology and Research, Singapore, Singapore, Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore

http://orcid.org/0000-0003-2187-7058

⨯
Luke N. Robinson,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Visterra Inc, Cambridge, Massachusetts, United States of America
⨯
Li Ching Ong,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Validation, Visualization

Affiliation Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
⨯
Kirk J. Rowley,

Roles Conceptualization, Data curation, Formal analysis, Validation, Visualization

Affiliation Visterra Inc, Cambridge, Massachusetts, United States of America
⨯
Alexander Winnett,

Roles Conceptualization, Data curation, Formal analysis, Validation, Visualization

Affiliation Visterra Inc, Cambridge, Massachusetts, United States of America
⨯
Hwee Cheng Tan,

Roles Conceptualization, Data curation, Formal analysis, Validation, Visualization

Affiliation Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore
⨯
Sven Hobbie,

Roles Conceptualization, Data curation, Formal analysis, Validation, Visualization

Affiliation Visterra Singapore International Pte Ltd, Singapore, Singapore
⨯
Zachary Shriver,

Roles Conceptualization, Data curation, Formal analysis, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Visterra Inc, Cambridge, Massachusetts, United States of America
⨯
Gregory J. Babcock,

Roles Conceptualization, Data curation, Formal analysis, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Visterra Inc, Cambridge, Massachusetts, United States of America
⨯
Sylvie Alonso,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Supervision

Affiliation Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
⨯
Eng Eong Ooi

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Infectious Diseases Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology, Singapore, Singapore, Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
⨯

Neutralization of antibody-enhanced dengue infection by VIS513, a pan serotype reactive monoclonal antibody targeting domain III of the dengue E protein

Yadunanda Budigi,
Eugenia Z. Ong,
Luke N. Robinson,
Li Ching Ong,
Kirk J. Rowley,
Alexander Winnett,
Hwee Cheng Tan,
Sven Hobbie,
Zachary Shriver,
Gregory J. Babcock

Published: February 9, 2018
https://doi.org/10.1371/journal.pntd.0006209

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