A tetravalent virus-like particle vaccine designed to display domain III of dengue envelope proteins induces multi-serotype neutralizing antibodies in mice and macaques which confer protection against antibody dependent enhancement in AG129 mice

• Viswanathan Ramasamy ,

  Contributed equally to this work with: Viswanathan Ramasamy, Upasana Arora

  Roles Investigation, Validation

  Affiliation Recombinant Gene Products Group, Molecular Medicine Division, International Centre for Genetic Engineering and Biotechnology, New Delhi, India

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• Upasana Arora ,

  Contributed equally to this work with: Viswanathan Ramasamy, Upasana Arora

  Roles Data curation, Formal analysis, Project administration

  Affiliation Recombinant Gene Products Group, Molecular Medicine Division, International Centre for Genetic Engineering and Biotechnology, New Delhi, India

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• Rahul Shukla,

  Roles Investigation, Validation

  Affiliation Recombinant Gene Products Group, Molecular Medicine Division, International Centre for Genetic Engineering and Biotechnology, New Delhi, India

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• Ankur Poddar,

  Roles Investigation, Validation

  Affiliation Recombinant Gene Products Group, Molecular Medicine Division, International Centre for Genetic Engineering and Biotechnology, New Delhi, India

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• Rajgokul K. Shanmugam,

  Roles Investigation, Validation

  Affiliation Recombinant Gene Products Group, Molecular Medicine Division, International Centre for Genetic Engineering and Biotechnology, New Delhi, India

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• Laura J. White,

  Roles Investigation, Resources, Validation

  Current address: Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Dental Circle, Burnett Womack, Chapel Hill, NC

  Affiliation Global Vaccines Inc., 801 Capitola Dr., Ste. 11, Durham, NC, United States of America

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• Melissa M. Mattocks,

  Roles Investigation, Validation

  Current address: Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Dental Circle, Burnett Womack, Chapel Hill, NC

  Affiliation Global Vaccines Inc., 801 Capitola Dr., Ste. 11, Durham, NC, United States of America

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• Rajendra Raut,

  Roles Investigation, Validation

  Affiliations Recombinant Gene Products Group, Molecular Medicine Division, International Centre for Genetic Engineering and Biotechnology, New Delhi, India, Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America

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• Ashiya Perween,

  Roles Investigation, Validation

  Affiliation Recombinant Gene Products Group, Molecular Medicine Division, International Centre for Genetic Engineering and Biotechnology, New Delhi, India

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• Poornima Tyagi,

  Roles Investigation, Validation

  Affiliation Recombinant Gene Products Group, Molecular Medicine Division, International Centre for Genetic Engineering and Biotechnology, New Delhi, India

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• Aravinda M. de Silva,

  Roles Methodology, Resources

  Affiliation Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America

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• Siddhartha K. Bhaumik,

  Roles Investigation, Validation

  Affiliation Department of Pediatrics, Division of Infectious Disease, Emory University School of Medicine, Atlanta, GA, United States of America

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• Murali Krishna Kaja,

  Roles Investigation, Validation

  Affiliations Department of Pediatrics, Division of Infectious Disease, Emory University School of Medicine, Atlanta, GA, United States of America, ICGEB-Emory Vaccine Center, International Centre for Genetic Engineering and Biotechnology, New Delhi, India, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, United States of America

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• François Villinger,

  Roles Investigation, Validation

  Current address: New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA

  Affiliation Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, United States of America

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• Rafi Ahmed,

  Roles Investigation, Validation

  Affiliation Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, United States of America

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• Robert E. Johnston,

  Roles Investigation, Validation

  Affiliation Global Vaccines Inc., 801 Capitola Dr., Ste. 11, Durham, NC, United States of America

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• Sathyamangalam Swaminathan ,

  Roles Conceptualization, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: swami@icgeb.res.in (SS); navinkhanna5@gmail.com, navin@icgeb.res.in (NK)

  Affiliation Recombinant Gene Products Group, Molecular Medicine Division, International Centre for Genetic Engineering and Biotechnology, New Delhi, India

  http://orcid.org/0000-0002-4388-2248

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•  [ ... ],
• Navin Khanna

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  * E-mail: swami@icgeb.res.in (SS); navinkhanna5@gmail.com, navin@icgeb.res.in (NK)

  Affiliations Recombinant Gene Products Group, Molecular Medicine Division, International Centre for Genetic Engineering and Biotechnology, New Delhi, India, Department of Pediatrics, Division of Infectious Disease, Emory University School of Medicine, Atlanta, GA, United States of America, Translational Health Science & Technology Institute, NCR Biotech Science Cluster, Faridabad, INDIA

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