Identification of novel leishmanicidal molecules by virtual and biochemical screenings targeting Leishmania eukaryotic translation initiation factor 4A

• Emna Harigua-Souiai ,

  Contributed equally to this work with: Emna Harigua-Souiai, Yosser Zina Abdelkrim, Imen Bassoumi-Jamoussi

  Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Laboratory of Molecular Epidemiology and Experimental Pathology – LR11IPT04, Institut Pasteur de Tunis, Université de Tunis el Manar, Tunis, Tunisia, Institut Pasteur, Unité de Bioinformatique Structurale, CNRS UMR 3528, Département de Biologie Structurale et Chimie, Paris, France

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• Yosser Zina Abdelkrim ,

  Contributed equally to this work with: Emna Harigua-Souiai, Yosser Zina Abdelkrim, Imen Bassoumi-Jamoussi

  Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Laboratory of Molecular Epidemiology and Experimental Pathology – LR11IPT04, Institut Pasteur de Tunis, Université de Tunis el Manar, Tunis, Tunisia, Laboratory of Microbial Gene Expression (EGM), CNRS UMR8261/Université Paris Diderot P7, Sorbonne Paris Cité & PSL, Institut de Biologie Physico-Chimique, Paris, France, Faculté des Sciences de Bizerte, Université de Carthage, Tunis, Tunisia

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• Imen Bassoumi-Jamoussi ,

  Contributed equally to this work with: Emna Harigua-Souiai, Yosser Zina Abdelkrim, Imen Bassoumi-Jamoussi

  Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Laboratory of Molecular Epidemiology and Experimental Pathology – LR11IPT04, Institut Pasteur de Tunis, Université de Tunis el Manar, Tunis, Tunisia

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• Ons Zakraoui ,

  Roles Investigation

  ¶‡ OZ and GB also contributed equally to this work.

  Affiliation Laboratory of Molecular Epidemiology and Experimental Pathology – LR11IPT04, Institut Pasteur de Tunis, Université de Tunis el Manar, Tunis, Tunisia

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• Guillaume Bouvier ,

  Roles Formal analysis, Investigation, Methodology, Software

  ¶‡ OZ and GB also contributed equally to this work.

  Affiliation Institut Pasteur, Unité de Bioinformatique Structurale, CNRS UMR 3528, Département de Biologie Structurale et Chimie, Paris, France

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• Khadija Essafi-Benkhadir,

  Roles Formal analysis, Investigation, Methodology, Resources, Supervision, Validation, Writing – review & editing

  Affiliation Laboratory of Molecular Epidemiology and Experimental Pathology – LR11IPT04, Institut Pasteur de Tunis, Université de Tunis el Manar, Tunis, Tunisia

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• Josette Banroques,

  Roles Investigation

  Affiliation Laboratory of Microbial Gene Expression (EGM), CNRS UMR8261/Université Paris Diderot P7, Sorbonne Paris Cité & PSL, Institut de Biologie Physico-Chimique, Paris, France

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• Nathan Desdouits,

  Roles Software

  Affiliation Institut Pasteur, Unité de Bioinformatique Structurale, CNRS UMR 3528, Département de Biologie Structurale et Chimie, Paris, France

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• Hélène Munier-Lehmann,

  Roles Methodology, Resources, Writing – review & editing

  Affiliations Institut Pasteur, Unité de Chimie et Biocatalyse, Département de Biologie Structurale et Chimie, Paris, France, Unité Mixte de Recherche 3523, Centre National de la Recherche Scientifique, Paris, France

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• Mourad Barhoumi,

  Roles Resources, Writing – review & editing

  Affiliation Laboratory of Molecular Epidemiology and Experimental Pathology – LR11IPT04, Institut Pasteur de Tunis, Université de Tunis el Manar, Tunis, Tunisia

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• N. Kyle Tanner,

  Roles Conceptualization, Investigation, Methodology, Resources, Supervision, Validation, Writing – review & editing

  Affiliation Laboratory of Microbial Gene Expression (EGM), CNRS UMR8261/Université Paris Diderot P7, Sorbonne Paris Cité & PSL, Institut de Biologie Physico-Chimique, Paris, France

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• Michael Nilges ,

  Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing

  * E-mail: michael.nilges@pasteur.fr (MN); ikram.guizani@pasteur.rns.tn (IG)

  Affiliation Institut Pasteur, Unité de Bioinformatique Structurale, CNRS UMR 3528, Département de Biologie Structurale et Chimie, Paris, France

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• Arnaud Blondel,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Writing – review & editing

  Affiliation Institut Pasteur, Unité de Bioinformatique Structurale, CNRS UMR 3528, Département de Biologie Structurale et Chimie, Paris, France

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• Ikram Guizani

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: michael.nilges@pasteur.fr (MN); ikram.guizani@pasteur.rns.tn (IG)

  Affiliation Laboratory of Molecular Epidemiology and Experimental Pathology – LR11IPT04, Institut Pasteur de Tunis, Université de Tunis el Manar, Tunis, Tunisia

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