4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection

• Claudia Magalhaes Calvet,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America, Cellular Ultra-Structure Laboratory, Oswaldo Cruz Institute (IOC), FIOCRUZ, Rio de Janeiro, Rio de Janeiro, Brazil

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• Jun Yong Choi,

  Roles Data curation, Methodology

  Affiliation Department of Chemistry, Scripps Florida, Jupiter, Florida, United States of America

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• Diane Thomas,

  Roles Conceptualization, Data curation, Investigation, Methodology, Writing – review & editing

  Affiliation Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America

  http://orcid.org/0000-0003-3101-6606

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• Brian Suzuki,

  Roles Data curation, Methodology

  Affiliation Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America

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• Ken Hirata,

  Roles Data curation, Methodology

  Affiliation Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America

  ⨯
• Sharon Lostracco-Johnson,

  Roles Data curation, Methodology

  Affiliation Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America

  ⨯
• Liliane Batista de Mesquita,

  Roles Data curation, Investigation, Methodology

  Affiliation Cellular Ultra-Structure Laboratory, Oswaldo Cruz Institute (IOC), FIOCRUZ, Rio de Janeiro, Rio de Janeiro, Brazil

  ⨯
• Alanderson Nogueira,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation Cellular Ultra-Structure Laboratory, Oswaldo Cruz Institute (IOC), FIOCRUZ, Rio de Janeiro, Rio de Janeiro, Brazil

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• Marcelo Meuser-Batista,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation Department of Pathologic Anatomy, Fernandes Figueira Institute (IFF), FIOCRUZ, Rio de Janeiro, Rio de Janeiro, Brazil

  ⨯
• Tatiana Araujo Silva,

  Roles Data curation, Investigation

  Affiliation Cellular Ultra-Structure Laboratory, Oswaldo Cruz Institute (IOC), FIOCRUZ, Rio de Janeiro, Rio de Janeiro, Brazil

  ⨯
• Jair Lage Siqueira-Neto,

  Roles Data curation, Methodology, Resources

  Affiliation Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America

  ⨯
• William R. Roush,

  Roles Funding acquisition, Methodology, Resources

  Affiliation Department of Chemistry, Scripps Florida, Jupiter, Florida, United States of America

  http://orcid.org/0000-0001-9785-5897

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• Mirian Claudia de Souza Pereira,

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision

  Affiliation Cellular Ultra-Structure Laboratory, Oswaldo Cruz Institute (IOC), FIOCRUZ, Rio de Janeiro, Rio de Janeiro, Brazil

  ⨯
• James H. McKerrow,

  Roles Funding acquisition, Methodology, Resources, Supervision

  Affiliation Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America

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• Larissa M. Podust

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: lpodust@ucsd.edu

  Affiliation Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America

  http://orcid.org/0000-0002-8537-8760

  ⨯