Csseverin inhibits apoptosis through mitochondria-mediated pathways triggered by Ca2 + dyshomeostasis in hepatocarcinoma PLC cells

Mengchen Shi; Lina Zhou; Lu Zhao; Mei Shang; Tongtong He; Zeli Tang; Hengchang Sun; Pengli Ren; Zhipeng Lin; Tingjin Chen; Jinyun Yu; Jin Xu; Xinbing Yu; Yan Huang

doi:10.1371/journal.pntd.0006074

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Open Access

Peer-reviewed

Research Article

Csseverin inhibits apoptosis through mitochondria-mediated pathways triggered by Ca^{2 +} dyshomeostasis in hepatocarcinoma PLC cells

Mengchen Shi,

Roles Funding acquisition, Investigation, Methodology, Writing – original draft

Affiliations Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China, Key Laboratory for Tropical Disease Control, Ministry of Education, Sun Yat-Sen University, Guangzhou, China, Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

http://orcid.org/0000-0002-9457-8211

⨯
Lina Zhou,

Roles Methodology

Affiliations Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China, Key Laboratory for Tropical Disease Control, Ministry of Education, Sun Yat-Sen University, Guangzhou, China, Guangdong Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China
⨯
Lu Zhao,

Roles Methodology

Affiliations Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China, Key Laboratory for Tropical Disease Control, Ministry of Education, Sun Yat-Sen University, Guangzhou, China, Guangdong Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China
⨯
Mei Shang,

Roles Resources

Affiliations Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China, Key Laboratory for Tropical Disease Control, Ministry of Education, Sun Yat-Sen University, Guangzhou, China, Guangdong Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China
⨯
Tongtong He,

Roles Formal analysis

Affiliation School of Public Health, Sun Yat-Sen University, Guangzhou, China
⨯
Zeli Tang,

Roles Conceptualization, Methodology

Affiliations Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China, Key Laboratory for Tropical Disease Control, Ministry of Education, Sun Yat-Sen University, Guangzhou, China, Guangdong Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China
⨯
Hengchang Sun,

Roles Methodology

Affiliations Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China, Key Laboratory for Tropical Disease Control, Ministry of Education, Sun Yat-Sen University, Guangzhou, China, Guangdong Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China
⨯
Pengli Ren,

Roles Methodology

Affiliations Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China, Key Laboratory for Tropical Disease Control, Ministry of Education, Sun Yat-Sen University, Guangzhou, China, Guangdong Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China
⨯
Zhipeng Lin,

Roles Methodology

Affiliations Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China, Key Laboratory for Tropical Disease Control, Ministry of Education, Sun Yat-Sen University, Guangzhou, China, Guangdong Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China
⨯
Tingjin Chen,

Roles Methodology

Affiliations Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China, Key Laboratory for Tropical Disease Control, Ministry of Education, Sun Yat-Sen University, Guangzhou, China, Guangdong Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China
⨯
Jinyun Yu,

Roles Methodology

Affiliations Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China, Key Laboratory for Tropical Disease Control, Ministry of Education, Sun Yat-Sen University, Guangzhou, China, Guangdong Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China
⨯
Jin Xu,

Roles Resources

Affiliations Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China, Key Laboratory for Tropical Disease Control, Ministry of Education, Sun Yat-Sen University, Guangzhou, China, Guangdong Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China
⨯
Xinbing Yu ,

Roles Resources

* E-mail: yuhxteam@163.com (XY); huang66@mail.sysu.edu.cn (YH)

Affiliations Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China, Key Laboratory for Tropical Disease Control, Ministry of Education, Sun Yat-Sen University, Guangzhou, China, Guangdong Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China
⨯
Yan Huang

Roles Supervision

* E-mail: yuhxteam@163.com (XY); huang66@mail.sysu.edu.cn (YH)

Affiliations Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China, Key Laboratory for Tropical Disease Control, Ministry of Education, Sun Yat-Sen University, Guangzhou, China, Guangdong Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China
⨯

Csseverin inhibits apoptosis through mitochondria-mediated pathways triggered by Ca^{2 +} dyshomeostasis in hepatocarcinoma PLC cells

Mengchen Shi,
Lina Zhou,
Lu Zhao,
Mei Shang,
Tongtong He,
Zeli Tang,
Hengchang Sun,
Pengli Ren,
Zhipeng Lin,
Tingjin Chen

Published: November 10, 2017
https://doi.org/10.1371/journal.pntd.0006074

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