Mitochondria and lipid raft-located F_OF₁-ATP synthase as major therapeutic targets in the antileishmanial and anticancer activities of ether lipid edelfosine

• Janny A. Villa-Pulgarín ,

  Contributed equally to this work with: Janny A. Villa-Pulgarín, Consuelo Gajate

  Roles Conceptualization, Investigation, Methodology, Validation, Visualization

  Affiliation Instituto de Biología Molecular y Celular del Cáncer, Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca, Spain

  ⨯
• Consuelo Gajate ,

  Contributed equally to this work with: Janny A. Villa-Pulgarín, Consuelo Gajate

  Roles Conceptualization, Investigation, Methodology, Validation

  Affiliations Instituto de Biología Molecular y Celular del Cáncer, Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca, Spain, Laboratory of Cell Death and Cancer Therapy, Department of Cellular and Molecular Medicine, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain

  ⨯
• Javier Botet,

  Roles Investigation

  Affiliation Metabolic Engineering Group, Departamento de Microbiología y Genética, Universidad de Salamanca, Edificio Departamental, Campus Miguel de Unamuno, Salamanca, Spain

  ⨯
• Alberto Jimenez,

  Roles Investigation

  Affiliation Metabolic Engineering Group, Departamento de Microbiología y Genética, Universidad de Salamanca, Edificio Departamental, Campus Miguel de Unamuno, Salamanca, Spain

  ⨯
• Nicole Justies,

  Roles Investigation

  Affiliation Department of Cellular Immunology, Max-Planck-Institut für Immunbiologie und Epigenetik, Freiburg, Germany

  ⨯
• Rubén E. Varela-M,

  Roles Investigation, Methodology

  Affiliation Instituto de Biología Molecular y Celular del Cáncer, Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca, Spain

  ⨯
• Álvaro Cuesta-Marbán,

  Roles Investigation

  Affiliation Instituto de Biología Molecular y Celular del Cáncer, Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca, Spain

  ⨯
• Ingrid Müller,

  Roles Investigation, Methodology

  Affiliation Department of Medicine, Section of Immunology, St. Mary’s Campus, Imperial College London, London, United Kingdom

  http://orcid.org/0000-0002-0050-4693

  ⨯
• Manuel Modolell,

  Roles Investigation, Methodology, Validation

  Affiliation Department of Cellular Immunology, Max-Planck-Institut für Immunbiologie und Epigenetik, Freiburg, Germany

  ⨯
• José L. Revuelta,

  Roles Investigation, Methodology, Validation, Visualization

  Affiliation Metabolic Engineering Group, Departamento de Microbiología y Genética, Universidad de Salamanca, Edificio Departamental, Campus Miguel de Unamuno, Salamanca, Spain

  ⨯
• Faustino Mollinedo

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: fmollin@cib.csic.es

  Affiliations Instituto de Biología Molecular y Celular del Cáncer, Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca, Spain, Laboratory of Cell Death and Cancer Therapy, Department of Cellular and Molecular Medicine, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain

  http://orcid.org/0000-0002-4939-2434

  ⨯