Soluble Egg Antigens of Schistosoma japonicum Induce Senescence of Activated Hepatic Stellate Cells by Activation of the FoxO3a/SKP2/P27 Pathway

Yinong Duan; Jing Pan; Jinling Chen; Dandan Zhu; Jianxin Wang; Xiaolei Sun; Liuting Chen; Liting Wu

doi:10.1371/journal.pntd.0005268

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Peer-reviewed

Research Article

Soluble Egg Antigens of Schistosoma japonicum Induce Senescence of Activated Hepatic Stellate Cells by Activation of the FoxO3a/SKP2/P27 Pathway

Yinong Duan ,

Contributed equally to this work with: Yinong Duan, Jing Pan

* E-mail: yinongduan@aliyun.com

Affiliation Department of Pathogen Biology, School of Medicine, Nantong University, Nantong, Jiangsu, People’s Republic of China

http://orcid.org/0000-0001-5824-5762

⨯
Jing Pan ,

Contributed equally to this work with: Yinong Duan, Jing Pan

Affiliations Department of Pathogen Biology, School of Medicine, Nantong University, Nantong, Jiangsu, People’s Republic of China, Department of Pathogen Biology and Immunology, Kangda College of Nanjing Medical University, Lianyungang, Jiangsu, People’s Republic of China
⨯
Jinling Chen,

Affiliation Department of Pathogen Biology, School of Medicine, Nantong University, Nantong, Jiangsu, People’s Republic of China
⨯
Dandan Zhu,

Affiliation Department of Pathogen Biology, School of Medicine, Nantong University, Nantong, Jiangsu, People’s Republic of China
⨯
Jianxin Wang,

Affiliation Laboratory Medicine Center, Affiliated Hospital of Nantong University, Nantong, Jiangsu, People’s Republic of China
⨯
Xiaolei Sun,

Affiliation Department of Pathogen Biology, School of Medicine, Nantong University, Nantong, Jiangsu, People’s Republic of China
⨯
Liuting Chen,

Affiliation Department of Pathogen Biology, School of Medicine, Nantong University, Nantong, Jiangsu, People’s Republic of China
⨯
Liting Wu

Affiliation Department of Pathogen Biology, School of Medicine, Nantong University, Nantong, Jiangsu, People’s Republic of China
⨯

Soluble Egg Antigens of Schistosoma japonicum Induce Senescence of Activated Hepatic Stellate Cells by Activation of the FoxO3a/SKP2/P27 Pathway

Yinong Duan,
Jing Pan,
Jinling Chen,
Dandan Zhu,
Jianxin Wang,
Xiaolei Sun,
Liuting Chen,
Liting Wu

Published: December 30, 2016
https://doi.org/10.1371/journal.pntd.0005268

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Liver fibrosis
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Cell staining
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Schistosoma japonicum
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Protein expression
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Eggs
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