Selective Inhibitor of Nuclear Export (SINE) Compounds Alter New World Alphavirus Capsid Localization and Reduce Viral Replication in Mammalian Cells

Lindsay Lundberg; Chelsea Pinkham; Cynthia de la Fuente; Ashwini Brahms; Nazly Shafagati; Kylie M. Wagstaff; David A. Jans; Sharon Tamir; Kylene Kehn-Hall

doi:10.1371/journal.pntd.0005122

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Peer-reviewed

Research Article

Selective Inhibitor of Nuclear Export (SINE) Compounds Alter New World Alphavirus Capsid Localization and Reduce Viral Replication in Mammalian Cells

Lindsay Lundberg,

Affiliation National Center for Biodefense and Infectious Diseases, School of Systems Biology, George Mason University, Manassas, Virginia, United States of America
⨯
Chelsea Pinkham,

Affiliation National Center for Biodefense and Infectious Diseases, School of Systems Biology, George Mason University, Manassas, Virginia, United States of America
⨯
Cynthia de la Fuente,

Affiliation National Center for Biodefense and Infectious Diseases, School of Systems Biology, George Mason University, Manassas, Virginia, United States of America
⨯
Ashwini Brahms,

Affiliation National Center for Biodefense and Infectious Diseases, School of Systems Biology, George Mason University, Manassas, Virginia, United States of America
⨯
Nazly Shafagati,

Affiliation National Center for Biodefense and Infectious Diseases, School of Systems Biology, George Mason University, Manassas, Virginia, United States of America
⨯
Kylie M. Wagstaff,

Affiliation Nuclear Signaling Laboratory, Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
⨯
David A. Jans,

Affiliation Nuclear Signaling Laboratory, Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
⨯
Sharon Tamir,

Affiliation Karyopharm Therapeutics Inc., Massachusetts, United States of America
⨯
Kylene Kehn-Hall

* E-mail: kkehnhal@gmu.edu

Affiliation National Center for Biodefense and Infectious Diseases, School of Systems Biology, George Mason University, Manassas, Virginia, United States of America
⨯

Selective Inhibitor of Nuclear Export (SINE) Compounds Alter New World Alphavirus Capsid Localization and Reduce Viral Replication in Mammalian Cells

Lindsay Lundberg,
Chelsea Pinkham,
Cynthia de la Fuente,
Ashwini Brahms,
Nazly Shafagati,
Kylie M. Wagstaff,
David A. Jans,
Sharon Tamir,
Kylene Kehn-Hall

Published: November 30, 2016
https://doi.org/10.1371/journal.pntd.0005122

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