Blockade of PD-1 Signaling Enhances Th2 Cell Responses and Aggravates Liver Immunopathology in Mice with Schistosomiasis japonica

Sha Zhou; Xin Jin; Yalin Li; Wei Li; Xiaojun Chen; Lei Xu; Jifeng Zhu; Zhipeng Xu; Yang Zhang; Feng Liu; Chuan Su

doi:10.1371/journal.pntd.0005094

Loading metrics

Open Access

Peer-reviewed

Research Article

Blockade of PD-1 Signaling Enhances Th2 Cell Responses and Aggravates Liver Immunopathology in Mice with Schistosomiasis japonica

Sha Zhou,

Affiliation Department of Pathogen Biology and Immunology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Xin Jin,

Affiliation Department of Pathogen Biology and Immunology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Yalin Li,

Affiliation Department of Pathogen Biology and Immunology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Wei Li,

Affiliation Department of Pathogen Biology and Immunology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Xiaojun Chen,

Affiliation Department of Pathogen Biology and Immunology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Lei Xu,

Affiliation Department of Pathogen Biology and Immunology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Jifeng Zhu,

Affiliation Department of Pathogen Biology and Immunology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Zhipeng Xu,

Affiliation Department of Pathogen Biology and Immunology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Yang Zhang,

Affiliation Department of Pathogen Biology and Immunology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Feng Liu,

Affiliation Department of Pathogen Biology and Immunology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China
⨯
Chuan Su

* E-mail: chuansu@njmu.edu.cn,

Affiliation Department of Pathogen Biology and Immunology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China
⨯

Blockade of PD-1 Signaling Enhances Th2 Cell Responses and Aggravates Liver Immunopathology in Mice with Schistosomiasis japonica

Sha Zhou,
Xin Jin,
Yalin Li,
Wei Li,
Xiaojun Chen,
Lei Xu,
Jifeng Zhu,
Zhipeng Xu,
Yang Zhang,
Feng Liu

Published: October 28, 2016
https://doi.org/10.1371/journal.pntd.0005094

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

T cells
Is the Subject Area "T cells" applicable to this article?

Thanks for your feedback.
Schistosoma
Is the Subject Area "Schistosoma" applicable to this article?

Thanks for your feedback.
Immunopathology
Is the Subject Area "Immunopathology" applicable to this article?

Thanks for your feedback.
Immune response
Is the Subject Area "Immune response" applicable to this article?

Thanks for your feedback.
Eggs
Is the Subject Area "Eggs" applicable to this article?

Thanks for your feedback.
Schistosoma japonicum
Is the Subject Area "Schistosoma japonicum" applicable to this article?

Thanks for your feedback.
Cloning
Is the Subject Area "Cloning" applicable to this article?

Thanks for your feedback.
T helper cells
Is the Subject Area "T helper cells" applicable to this article?

Thanks for your feedback.