Preclinical Study of Single-Dose Moxidectin, a New Oral Treatment for Scabies: Efficacy, Safety, and Pharmacokinetics Compared to Two-Dose Ivermectin in a Porcine Model

• Charlotte Bernigaud ,

  * E-mail: charlotte.bernigaud@univ-paris-est.fr

  Affiliations Research Group Dynamyc, EA 7380, EnvA, Université Paris-Est (UPE), Maisons-Alfort & Créteil, France, APHP, Hôpital Henri-Mondor, Department of Dermatology, UPEC, Créteil, France

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• Fang Fang ,

  Contributed equally to this work with: Fang Fang, Katja Fischer, Anne Lespine

  Affiliations Research Group Dynamyc, EA 7380, EnvA, Université Paris-Est (UPE), Maisons-Alfort & Créteil, France, Department of Parasitology, College of Animal Science and Technology, University of Guangxi, Nanning, China

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• Katja Fischer ,

  Contributed equally to this work with: Fang Fang, Katja Fischer, Anne Lespine

  Affiliation Infections Diseases Department, Scabies Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

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• Anne Lespine ,

  Contributed equally to this work with: Fang Fang, Katja Fischer, Anne Lespine

  Affiliation Toxalim, INRA, INP-ENVT, INP-EI-Purpan, Université de Toulouse III Paul Sabatier, Toulouse, France

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• Ludwig Serge Aho,

  Affiliation Epidemiology and Infection Control Unit, University Hospital of Dijon, Dijon, France

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• Dominique Dreau,

  Affiliation Cecaveto, Saint-Allouestre, France

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• Andrew Kelly,

  Affiliation Department of Agriculture, Fisheries and Forestry, Queensland Animal Science Precinct, University of Queensland, Gatton Campus, Queensland, Australia

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• Jean-François Sutra,

  Affiliation Toxalim, INRA, INP-ENVT, INP-EI-Purpan, Université de Toulouse III Paul Sabatier, Toulouse, France

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• Francis Moreau,

  Affiliation Centre de Recherche BioMédicale (CRBM), EnvA, UPE, Maisons-Alfort, France

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• Thomas Lilin,

  Affiliation Centre de Recherche BioMédicale (CRBM), EnvA, UPE, Maisons-Alfort, France

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• Françoise Botterel ,

  ¶‡ FB, JG, and OC also contributed equally to this work.

  Affiliations Research Group Dynamyc, EA 7380, EnvA, Université Paris-Est (UPE), Maisons-Alfort & Créteil, France, APHP, Hôpital Henri-Mondor, Parasitology and Mycology, Department of Microbiology, DHU VIC, UPEC, Créteil, France

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• Jacques Guillot ,

  ¶‡ FB, JG, and OC also contributed equally to this work.

  Affiliations Research Group Dynamyc, EA 7380, EnvA, Université Paris-Est (UPE), Maisons-Alfort & Créteil, France, Department of Parasitology and Mycology, Biopôle d'Alfort, Ecole nationale vétérinaire d'Alfort, UPE, Maisons-Alfort, France

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• Olivier Chosidow

  ¶‡ FB, JG, and OC also contributed equally to this work.

  Affiliations APHP, Hôpital Henri-Mondor, Department of Dermatology, UPEC, Créteil, France, EA EpiDermE (Epidémiologie en Dermatologie et Evaluation des Thérapeutiques) and INSERM, CIC 1430, UPE, Créteil, France

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