Leptospira Immunoglobulin-Like Protein B (LigB) Binds to Both the C-Terminal 23 Amino Acids of Fibrinogen αC Domain and Factor XIII: Insight into the Mechanism of LigB-Mediated Blockage of Fibrinogen α Chain Cross-Linking

Ching-Lin Hsieh; Eric Chang; Andrew Tseng; Christopher Ptak; Li-Chen Wu; Chun-Li Su; Sean P. McDonough; Yi-Pin Lin; Yung-Fu Chang

doi:10.1371/journal.pntd.0004974

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Research Article

Leptospira Immunoglobulin-Like Protein B (LigB) Binds to Both the C-Terminal 23 Amino Acids of Fibrinogen αC Domain and Factor XIII: Insight into the Mechanism of LigB-Mediated Blockage of Fibrinogen α Chain Cross-Linking

Ching-Lin Hsieh,

Affiliation Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America
⨯
Eric Chang,

Affiliation Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America
⨯
Andrew Tseng,

Affiliation Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America
⨯
Christopher Ptak,

Affiliation Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America
⨯
Li-Chen Wu,

Affiliation Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America
⨯
Chun-Li Su,

Affiliation Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America
⨯
Sean P. McDonough,

Affiliation Department of Biomedical Science, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America
⨯
Yi-Pin Lin,

Affiliation Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, New York, United States of America
⨯
Yung-Fu Chang

* E-mail: yc42@cornell.edu

Affiliation Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America
⨯

Leptospira Immunoglobulin-Like Protein B (LigB) Binds to Both the C-Terminal 23 Amino Acids of Fibrinogen αC Domain and Factor XIII: Insight into the Mechanism of LigB-Mediated Blockage of Fibrinogen α Chain Cross-Linking

Ching-Lin Hsieh,
Eric Chang,
Andrew Tseng,
Christopher Ptak,
Li-Chen Wu,
Chun-Li Su,
Sean P. McDonough,
Yi-Pin Lin,
Yung-Fu Chang

Published: September 13, 2016
https://doi.org/10.1371/journal.pntd.0004974

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