Live Attenuated Leishmania donovani Centrin Knock Out Parasites Generate Non-inferior Protective Immune Response in Aged Mice against Visceral Leishmaniasis

• Parna Bhattacharya ,

  * E-mail: Parna.Bhattacharya@fda.hhs.gov (PB); Hira.Nakhasi@fda.hhs.gov (HLN)

  Affiliation Division of Emerging and Transfusion Transmitted Disease, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America

  ⨯
• Ranadhir Dey,

  Affiliation Division of Emerging and Transfusion Transmitted Disease, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America

  ⨯
• Pradeep K. Dagur,

  Affiliation Flow Cytometry Core, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America

  ⨯
• Amritanshu B. Joshi,

  Affiliation Division of Emerging and Transfusion Transmitted Disease, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America

  ⨯
• Nevien Ismail,

  Affiliation Division of Emerging and Transfusion Transmitted Disease, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America

  ⨯
• Sreenivas Gannavaram,

  Affiliation Division of Emerging and Transfusion Transmitted Disease, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America

  ⨯
• Alain Debrabant,

  Affiliation Division of Emerging and Transfusion Transmitted Disease, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America

  ⨯
• Adovi D. Akue,

  Affiliation Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Silver Spring, Maryland, United States of America

  ⨯
• Mark A. KuKuruga,

  Affiliation Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Silver Spring, Maryland, United States of America

  ⨯
• Angamuthu Selvapandiyan,

  Affiliation Institute of Molecular Medicine, New Delhi, India

  ⨯
• John Philip McCoy Jr.,

  Affiliation Flow Cytometry Core, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America

  ⨯
• Hira L. Nakhasi

  * E-mail: Parna.Bhattacharya@fda.hhs.gov (PB); Hira.Nakhasi@fda.hhs.gov (HLN)

  Affiliation Division of Emerging and Transfusion Transmitted Disease, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America

  ⨯