Reduced Mitochondrial Membrane Potential Is a Late Adaptation of Trypanosoma brucei brucei to Isometamidium Preceded by Mutations in the γ Subunit of the F1Fo-ATPase

Anthonius A. Eze; Matthew K. Gould; Jane C. Munday; Daniel N. A. Tagoe; Valters Stelmanis; Achim Schnaufer; Harry P. De Koning

doi:10.1371/journal.pntd.0004791

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Research Article

Reduced Mitochondrial Membrane Potential Is a Late Adaptation of Trypanosoma brucei brucei to Isometamidium Preceded by Mutations in the γ Subunit of the F₁F_o-ATPase

Anthonius A. Eze ,

Contributed equally to this work with: Anthonius A. Eze, Matthew K. Gould

Current address: Department of Medical Biochemistry, University of Nigeria, Enugu Campus, Enugu, Nigeria

Affiliation Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
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Matthew K. Gould ,

Contributed equally to this work with: Anthonius A. Eze, Matthew K. Gould

Current address: Biocenter, Section Genetics, Ludwig-Maximilians-Universität München, Martinsried, Germany

Affiliation Institute for Immunology and Infection Research and Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
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Jane C. Munday,

Affiliation Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
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Daniel N. A. Tagoe,

Current address: Department of Biology, Boston College, Newton, Massachusetts, United States of America

Affiliations Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, Glasgow, United Kingdom
⨯
Valters Stelmanis,

Affiliation Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
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Achim Schnaufer,

Affiliation Institute for Immunology and Infection Research and Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
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Harry P. De Koning

* E-mail: Harry.de-Koning@glasgow.ac.uk

Affiliation Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

http://orcid.org/0000-0002-9963-1827

⨯

Reduced Mitochondrial Membrane Potential Is a Late Adaptation of Trypanosoma brucei brucei to Isometamidium Preceded by Mutations in the γ Subunit of the F₁F_o-ATPase

Anthonius A. Eze,
Matthew K. Gould,
Jane C. Munday,
Daniel N. A. Tagoe,
Valters Stelmanis,
Achim Schnaufer,
Harry P. De Koning

Published: August 12, 2016
https://doi.org/10.1371/journal.pntd.0004791

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