Vaccination of Gerbils with Bm-103 and Bm-RAL-2 Concurrently or as a Fusion Protein Confers Consistent and Improved Protection against Brugia malayi Infection

Sridhar Arumugam; Junfei Wei; Zhuyun Liu; David Abraham; Aaron Bell; Maria Elena Bottazzi; Peter J. Hotez; Bin Zhan; Sara Lustigman; Thomas R. Klei

doi:10.1371/journal.pntd.0004586

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Open Access

Peer-reviewed

Research Article

Vaccination of Gerbils with Bm-103 and Bm-RAL-2 Concurrently or as a Fusion Protein Confers Consistent and Improved Protection against Brugia malayi Infection

Sridhar Arumugam,

Affiliation Department of Pathobiological Sciences, LSU School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, United States of America
⨯
Junfei Wei,

Affiliation Sabin Vaccine Institute and Texas Children’s Hospital Center for Vaccine Development, National School of Tropical Medicine, Houston, Texas, United States of America
⨯
Zhuyun Liu,

Affiliation Sabin Vaccine Institute and Texas Children’s Hospital Center for Vaccine Development, National School of Tropical Medicine, Houston, Texas, United States of America
⨯
David Abraham,

Affiliation Department of Microbiology and Immunology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Aaron Bell,

Affiliation Laboratory of Molecular Parasitology, Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, United States of America
⨯
Maria Elena Bottazzi,

Affiliation Sabin Vaccine Institute and Texas Children’s Hospital Center for Vaccine Development, National School of Tropical Medicine, Houston, Texas, United States of America
⨯
Peter J. Hotez,

Affiliation Sabin Vaccine Institute and Texas Children’s Hospital Center for Vaccine Development, National School of Tropical Medicine, Houston, Texas, United States of America
⨯
Bin Zhan,

Affiliation Sabin Vaccine Institute and Texas Children’s Hospital Center for Vaccine Development, National School of Tropical Medicine, Houston, Texas, United States of America
⨯
Sara Lustigman ,

* E-mail: slustigman@nybloodcenter.org (SL); tklei1@lsu.edu (TRK)

Affiliation Laboratory of Molecular Parasitology, Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, United States of America
⨯
Thomas R. Klei

* E-mail: slustigman@nybloodcenter.org (SL); tklei1@lsu.edu (TRK)

Affiliation Department of Pathobiological Sciences, LSU School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, United States of America
⨯

Vaccination of Gerbils with Bm-103 and Bm-RAL-2 Concurrently or as a Fusion Protein Confers Consistent and Improved Protection against Brugia malayi Infection

Sridhar Arumugam,
Junfei Wei,
Zhuyun Liu,
David Abraham,
Aaron Bell,
Maria Elena Bottazzi,
Peter J. Hotez,
Bin Zhan,
Sara Lustigman,
Thomas R. Klei

Published: April 5, 2016
https://doi.org/10.1371/journal.pntd.0004586

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