Maternal Antibody-Mediated Disease Enhancement in Type I Interferon-Deficient Mice Leads to Lethal Disease Associated with Liver Damage

Julia María Martínez Gómez; Li Ching Ong; Jian Hang Lam; Siti Amanlina Binte Aman; Eshele Anak Libau; Pei Xuan Lee; Ashley L. St. John; Sylvie Alonso

doi:10.1371/journal.pntd.0004536

Loading metrics

Open Access

Peer-reviewed

Research Article

Maternal Antibody-Mediated Disease Enhancement in Type I Interferon-Deficient Mice Leads to Lethal Disease Associated with Liver Damage

Julia María Martínez Gómez ,

Contributed equally to this work with: Julia María Martínez Gómez, Li Ching Ong

Affiliations Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Immunology programme, Life Sciences Institute, National University of Singapore, Singapore
⨯
Li Ching Ong ,

Contributed equally to this work with: Julia María Martínez Gómez, Li Ching Ong

Affiliation Infectious Disease programme, Singapore-MIT alliance for Research and Technology (SMART), National University of Singapore, Singapore
⨯
Jian Hang Lam,

Affiliations Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Immunology programme, Life Sciences Institute, National University of Singapore, Singapore
⨯
Siti Amanlina Binte Aman,

Affiliation Emerging Infectious Diseases programme, Duke-NUS, Singapore
⨯
Eshele Anak Libau,

Affiliations Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Immunology programme, Life Sciences Institute, National University of Singapore, Singapore
⨯
Pei Xuan Lee,

Affiliations Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Immunology programme, Life Sciences Institute, National University of Singapore, Singapore
⨯
Ashley L. St. John,

Affiliation Emerging Infectious Diseases programme, Duke-NUS, Singapore
⨯
Sylvie Alonso

* E-mail: micas@nus.edu.sg

Affiliations Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Immunology programme, Life Sciences Institute, National University of Singapore, Singapore, Infectious Disease programme, Singapore-MIT alliance for Research and Technology (SMART), National University of Singapore, Singapore
⨯

Maternal Antibody-Mediated Disease Enhancement in Type I Interferon-Deficient Mice Leads to Lethal Disease Associated with Liver Damage

Julia María Martínez Gómez,
Li Ching Ong,
Jian Hang Lam,
Siti Amanlina Binte Aman,
Eshele Anak Libau,
Pei Xuan Lee,
Ashley L. St. John,
Sylvie Alonso

Published: March 23, 2016
https://doi.org/10.1371/journal.pntd.0004536

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Dengue fever
Is the Subject Area "Dengue fever" applicable to this article?

Thanks for your feedback.
Antibodies
Is the Subject Area "Antibodies" applicable to this article?

Thanks for your feedback.
Dengue virus
Is the Subject Area "Dengue virus" applicable to this article?

Thanks for your feedback.
Cytokines
Is the Subject Area "Cytokines" applicable to this article?

Thanks for your feedback.
Viremia
Is the Subject Area "Viremia" applicable to this article?

Thanks for your feedback.
Enzyme-linked immunoassays
Is the Subject Area "Enzyme-linked immunoassays" applicable to this article?

Thanks for your feedback.
Animal models of infection
Is the Subject Area "Animal models of infection" applicable to this article?

Thanks for your feedback.