Successful Treatment of Human Visceral Leishmaniasis Restores Antigen-Specific IFN-γ, but not IL-10 Production

Emebet Adem; Fitsumbirhan Tajebe; Mulusew Getahun; Amare Kiflie; Ermias Diro; Asrat Hailu; Ziv Shkedy; Bewketu Mengesha; Tadele Mulaw; Saba Atnafu; Tekalign Deressa; Biniam Mathewos; Ebba Abate; Manuel Modolell; Markus Munder; Ingrid Müller; Yegnasew Takele; Pascale Kropf

doi:10.1371/journal.pntd.0004468

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Research Article

Successful Treatment of Human Visceral Leishmaniasis Restores Antigen-Specific IFN-γ, but not IL-10 Production

Emebet Adem,

Affiliation Department of Immunology, University of Gondar, Ethiopia
⨯
Fitsumbirhan Tajebe,

Affiliation Department of Immunology, University of Gondar, Ethiopia
⨯
Mulusew Getahun,

Affiliation Department of Immunology, University of Gondar, Ethiopia
⨯
Amare Kiflie,

Affiliation Department of Immunology, University of Gondar, Ethiopia
⨯
Ermias Diro,

Affiliation Department of Internal Medicine, University of Gondar, Ethiopia
⨯
Asrat Hailu,

Affiliation Department of Microbiology, Immunology and Parasitology, Addis Ababa University, Ethiopia
⨯
Ziv Shkedy,

Affiliation Department of Mathematics and Statistics, University of Hasselt, Belgium
⨯
Bewketu Mengesha,

Affiliation Leishmaniasis Research and Treatment Centre, Gondar University, Ethiopia
⨯
Tadele Mulaw,

Affiliation Leishmaniasis Research and Treatment Centre, Gondar University, Ethiopia
⨯
Saba Atnafu,

Affiliation Leishmaniasis Research and Treatment Centre, Gondar University, Ethiopia
⨯
Tekalign Deressa,

Affiliation Department of Immunology, University of Gondar, Ethiopia
⨯
Biniam Mathewos,

Affiliation Department of Immunology, University of Gondar, Ethiopia
⨯
Ebba Abate,

Affiliation Department of Immunology, University of Gondar, Ethiopia
⨯
Manuel Modolell,

Affiliation Department of Cellular Immunology, Max-Planck-Institute for Immunobiology and Epigenetics, Freiburg, Germany
⨯
Markus Munder,

Affiliation Third Department of Medicine (Hematology, Oncology, and Pneumology), University Medical Center Mainz, Mainz, Germany
⨯
Ingrid Müller,

Affiliation Department of Medicine, Imperial College London, London, United Kingdom
⨯
Yegnasew Takele,

Affiliations Leishmaniasis Research and Treatment Centre, Gondar University, Ethiopia, Department of Medicine, Imperial College London, London, United Kingdom
⨯
[ ... ],
Pascale Kropf

* E-mail: p.kropf@imperial.ac.uk

Affiliation Department of Medicine, Imperial College London, London, United Kingdom
⨯
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Successful Treatment of Human Visceral Leishmaniasis Restores Antigen-Specific IFN-γ, but not IL-10 Production

Emebet Adem,
Fitsumbirhan Tajebe,
Mulusew Getahun,
Amare Kiflie,
Ermias Diro,
Asrat Hailu,
Ziv Shkedy,
Bewketu Mengesha,
Tadele Mulaw,
Saba Atnafu

Published: March 10, 2016
https://doi.org/10.1371/journal.pntd.0004468

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