Delayed Time-to-Treatment of an Antisense Morpholino Oligomer Is Effective against Lethal Marburg Virus Infection in Cynomolgus Macaques

Travis K. Warren; Chris A. Whitehouse; Jay Wells; Lisa Welch; Jay S. Charleston; Alison Heald; Donald K. Nichols; Marc E. Mattix; Gustavo Palacios; Jeffrey R. Kugleman; Patrick L. Iversen; Sina Bavari

doi:10.1371/journal.pntd.0004456

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Open Access

Peer-reviewed

Research Article

Delayed Time-to-Treatment of an Antisense Morpholino Oligomer Is Effective against Lethal Marburg Virus Infection in Cynomolgus Macaques

Travis K. Warren,

Affiliation Molecular and Translational Sciences Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America
⨯
Chris A. Whitehouse,

Affiliation Molecular and Translational Sciences Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America
⨯
Jay Wells,

Affiliation Molecular and Translational Sciences Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America
⨯
Lisa Welch,

Affiliation Molecular and Translational Sciences Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America
⨯
Jay S. Charleston,

Affiliation Sarepta Therapeutics, Inc., Cambridge, Massachusetts, United States of America
⨯
Alison Heald,

Affiliation Sarepta Therapeutics, Inc., Cambridge, Massachusetts, United States of America
⨯
Donald K. Nichols,

Affiliation Pathology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America
⨯
Marc E. Mattix,

Current address: WIL Research, Ashland, Ohio, United States of America

Affiliation Pathology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America
⨯
Gustavo Palacios,

Affiliation Center for Genome Sciences, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America
⨯
Jeffrey R. Kugleman,

Affiliation Center for Genome Sciences, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America
⨯
Patrick L. Iversen,

Affiliation Sarepta Therapeutics, Inc., Cambridge, Massachusetts, United States of America
⨯
Sina Bavari

* E-mail: sina.bavari.civ@mail.mil

Affiliation Molecular and Translational Sciences Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America
⨯

Delayed Time-to-Treatment of an Antisense Morpholino Oligomer Is Effective against Lethal Marburg Virus Infection in Cynomolgus Macaques

Travis K. Warren,
Chris A. Whitehouse,
Jay Wells,
Lisa Welch,
Jay S. Charleston,
Alison Heald,
Donald K. Nichols,
Marc E. Mattix,
Gustavo Palacios,
Jeffrey R. Kugleman

Published: February 22, 2016
https://doi.org/10.1371/journal.pntd.0004456

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