Oral Efficacy of Apigenin against Cutaneous Leishmaniasis: Involvement of Reactive Oxygen Species and Autophagy as a Mechanism of Action

Open Access

Peer-reviewed

Research Article

Fernanda Fonseca-Silva,

Affiliation Laboratório de Bioquímica de Tripanosomatídeos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Manguinhos, Rio de Janeiro, Brazil
⨯
Job D. F. Inacio,

Affiliation Laboratório de Bioquímica de Tripanosomatídeos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Manguinhos, Rio de Janeiro, Brazil
⨯
Marilene M. Canto-Cavalheiro,

Affiliation Laboratório de Bioquímica de Tripanosomatídeos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Manguinhos, Rio de Janeiro, Brazil
⨯
Rubem F. S. Menna-Barreto,

Affiliation Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Manguinhos, Rio de Janeiro, Brazil
⨯
Elmo E. Almeida-Amaral

* E-mail: elmo@ioc.fiocruz.br

Affiliation Laboratório de Bioquímica de Tripanosomatídeos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Manguinhos, Rio de Janeiro, Brazil
⨯

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Macrophages
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Parasitic diseases
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Amastigotes
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Toxicity
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Autophagic cell death
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Leishmaniasis
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Promastigotes
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Parasitophorous vacuole
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