An Anti-proteome Nanobody Library Approach Yields a Specific Immunoassay for Trypanosoma congolense Diagnosis Targeting Glycosomal Aldolase

Steven Odongo; Yann G. J. Sterckx; Benoît Stijlemans; Davita Pillay; Théo Baltz; Serge Muyldermans; Stefan Magez

doi:10.1371/journal.pntd.0004420

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Peer-reviewed

Research Article

An Anti-proteome Nanobody Library Approach Yields a Specific Immunoassay for Trypanosoma congolense Diagnosis Targeting Glycosomal Aldolase

Steven Odongo ,

* E-mail: sodongo@vub.ac.be, opodongo@covab.mak.ac.ug

Affiliations Laboratory of Cellular and Molecular Immunology (CMIM), Vrije Universiteit Brussel, Brussels, Belgium, Structural Biology Research Center, Vlaams Instituut voor Biotechnologie (VIB), Brussels, Belgium, Department of Biotechnical and Diagnostic Sciences, College of Veterinary Medicine, Animal Resources and Bio-security (COVAB), Makerere University, Kampala, Uganda
⨯
Yann G. J. Sterckx,

Affiliations Laboratory of Cellular and Molecular Immunology (CMIM), Vrije Universiteit Brussel, Brussels, Belgium, Structural Biology Research Center, Vlaams Instituut voor Biotechnologie (VIB), Brussels, Belgium
⨯
Benoît Stijlemans,

Affiliations Laboratory of Cellular and Molecular Immunology (CMIM), Vrije Universiteit Brussel, Brussels, Belgium, Laboratory of Myeloid Cell Immunology, VIB Inflammation Research Center, Ghent, Belgium
⨯
Davita Pillay,

Affiliation Microbiologie Fondamentale et Pathogénicité, Centre National de la Recherche Scientifique, Université Bordeaux, Bordeaux, France
⨯
Théo Baltz,

Affiliation Microbiologie Fondamentale et Pathogénicité, Centre National de la Recherche Scientifique, Université Bordeaux, Bordeaux, France
⨯
Serge Muyldermans,

Affiliation Laboratory of Cellular and Molecular Immunology (CMIM), Vrije Universiteit Brussel, Brussels, Belgium
⨯
Stefan Magez

Affiliations Laboratory of Cellular and Molecular Immunology (CMIM), Vrije Universiteit Brussel, Brussels, Belgium, Structural Biology Research Center, Vlaams Instituut voor Biotechnologie (VIB), Brussels, Belgium
⨯

An Anti-proteome Nanobody Library Approach Yields a Specific Immunoassay for Trypanosoma congolense Diagnosis Targeting Glycosomal Aldolase

Steven Odongo,
Yann G. J. Sterckx,
Benoît Stijlemans,
Davita Pillay,
Théo Baltz,
Serge Muyldermans,
Stefan Magez

Published: February 2, 2016
https://doi.org/10.1371/journal.pntd.0004420

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Enzyme-linked immunoassays
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