Efficacy, Safety, and Dose of Pafuramidine, a New Oral Drug for Treatment of First Stage Sleeping Sickness, in a Phase 2a Clinical Study and Phase 2b Randomized Clinical Studies

• Christian Burri ,

  ¶‡ CB, PDY, JLA, CAO, JB, RRT and GP are primary authors and contributed equally to this work. AMe, KS, AMp, PL, VKBKM, CMMB, JPFL, AMM, MT, BFM, FM, TJ and SCB are secondary authors who contributed equally to this work.

  Affiliations Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

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• Patrick D. Yeramian ,

  ¶‡ CB, PDY, JLA, CAO, JB, RRT and GP are primary authors and contributed equally to this work. AMe, KS, AMp, PL, VKBKM, CMMB, JPFL, AMM, MT, BFM, FM, TJ and SCB are secondary authors who contributed equally to this work.

  Affiliation The Vaccine and Gene Therapy Institute of Florida, Port St. Lucie, Florida, United States of America

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• James L. Allen †,

  † Deceased.

  ¶‡ CB, PDY, JLA, CAO, JB, RRT and GP are primary authors and contributed equally to this work. AMe, KS, AMp, PL, VKBKM, CMMB, JPFL, AMM, MT, BFM, FM, TJ and SCB are secondary authors who contributed equally to this work.

  Affiliation Immtech Pharmaceuticals, Inc., Vernon Hills, Illinois, United States of America

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• Ada Merolle ,

  ¶‡ CB, PDY, JLA, CAO, JB, RRT and GP are primary authors and contributed equally to this work. AMe, KS, AMp, PL, VKBKM, CMMB, JPFL, AMM, MT, BFM, FM, TJ and SCB are secondary authors who contributed equally to this work.

  Affiliation The QED group, Luanda, Angola

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• Kazadi Kyanza Serge ,

  ¶‡ CB, PDY, JLA, CAO, JB, RRT and GP are primary authors and contributed equally to this work. AMe, KS, AMp, PL, VKBKM, CMMB, JPFL, AMM, MT, BFM, FM, TJ and SCB are secondary authors who contributed equally to this work.

  Affiliation Médecins sans Frontières Suisse, Genève, Suisse

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• Alain Mpanya ,

  ¶‡ CB, PDY, JLA, CAO, JB, RRT and GP are primary authors and contributed equally to this work. AMe, KS, AMp, PL, VKBKM, CMMB, JPFL, AMM, MT, BFM, FM, TJ and SCB are secondary authors who contributed equally to this work.

  Affiliation Lisumbi Health Centre, Kinshasa, Democratic Republic of the Congo

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• Pascal Lutumba ,

  ¶‡ CB, PDY, JLA, CAO, JB, RRT and GP are primary authors and contributed equally to this work. AMe, KS, AMp, PL, VKBKM, CMMB, JPFL, AMM, MT, BFM, FM, TJ and SCB are secondary authors who contributed equally to this work.

  Affiliation Institut National de Recherche Biomédicale and Tropical Medicine Department, Kinshasa University, Kinshasa, Democratic Republic of the Congo

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• Victor Kande Betu Ku Mesu ,

  ¶‡ CB, PDY, JLA, CAO, JB, RRT and GP are primary authors and contributed equally to this work. AMe, KS, AMp, PL, VKBKM, CMMB, JPFL, AMM, MT, BFM, FM, TJ and SCB are secondary authors who contributed equally to this work.

  Affiliation Programme des Maladies Tropicales Négligées, Ministère de la Santé Publique Kinshasa, Democratic Republic of the Congo

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• Constantin Miaka Mia Bilenge †,

  † Deceased.

  ¶‡ CB, PDY, JLA, CAO, JB, RRT and GP are primary authors and contributed equally to this work. AMe, KS, AMp, PL, VKBKM, CMMB, JPFL, AMM, MT, BFM, FM, TJ and SCB are secondary authors who contributed equally to this work.

  Affiliation Ministry of Health, Kinshasa, Democratic Republic of the Congo

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• Jean-Pierre Fina Lubaki ,

  ¶‡ CB, PDY, JLA, CAO, JB, RRT and GP are primary authors and contributed equally to this work. AMe, KS, AMp, PL, VKBKM, CMMB, JPFL, AMM, MT, BFM, FM, TJ and SCB are secondary authors who contributed equally to this work.

  Affiliation Hôspital Evangélique de Vanga, Vanga, Democratic Republic of the Congo

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• Alfred Mpoo Mpoto ,

  ¶‡ CB, PDY, JLA, CAO, JB, RRT and GP are primary authors and contributed equally to this work. AMe, KS, AMp, PL, VKBKM, CMMB, JPFL, AMM, MT, BFM, FM, TJ and SCB are secondary authors who contributed equally to this work.

  Affiliation Hôspital Evangélique de Vanga, Vanga, Democratic Republic of the Congo

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• Mark Thompson ,

  ¶‡ CB, PDY, JLA, CAO, JB, RRT and GP are primary authors and contributed equally to this work. AMe, KS, AMp, PL, VKBKM, CMMB, JPFL, AMM, MT, BFM, FM, TJ and SCB are secondary authors who contributed equally to this work.

  Affiliation Federally Qualified Community Health Center, Elgin, Illinois, United States of America

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• Blaise Fungula Munungu ,

  ¶‡ CB, PDY, JLA, CAO, JB, RRT and GP are primary authors and contributed equally to this work. AMe, KS, AMp, PL, VKBKM, CMMB, JPFL, AMM, MT, BFM, FM, TJ and SCB are secondary authors who contributed equally to this work.

  Affiliation Lisumbi Health Centre, Kinshasa, Democratic Republic of the Congo

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• Francisco Manuel †,

  † Deceased.

  ¶‡ CB, PDY, JLA, CAO, JB, RRT and GP are primary authors and contributed equally to this work. AMe, KS, AMp, PL, VKBKM, CMMB, JPFL, AMM, MT, BFM, FM, TJ and SCB are secondary authors who contributed equally to this work.

  Affiliation Instituto de Combate e de Controlo das Tripanossomíases, Luanda, Angola

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• Théophilo Josenando ,

  ¶‡ CB, PDY, JLA, CAO, JB, RRT and GP are primary authors and contributed equally to this work. AMe, KS, AMp, PL, VKBKM, CMMB, JPFL, AMM, MT, BFM, FM, TJ and SCB are secondary authors who contributed equally to this work.

  Affiliation Instituto de Combate e de Controlo das Tripanossomíases, Luanda, Angola

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• Sonja C. Bernhard ,

  ¶‡ CB, PDY, JLA, CAO, JB, RRT and GP are primary authors and contributed equally to this work. AMe, KS, AMp, PL, VKBKM, CMMB, JPFL, AMM, MT, BFM, FM, TJ and SCB are secondary authors who contributed equally to this work.

  Affiliations Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

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• Carol A. Olson ,

  ¶‡ CB, PDY, JLA, CAO, JB, RRT and GP are primary authors and contributed equally to this work. AMe, KS, AMp, PL, VKBKM, CMMB, JPFL, AMM, MT, BFM, FM, TJ and SCB are secondary authors who contributed equally to this work.

  Affiliation Infectious Diseases, Global Product Development, PPD, Rockville, Maryland, United States of America

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• Johannes Blum ,

  ¶‡ CB, PDY, JLA, CAO, JB, RRT and GP are primary authors and contributed equally to this work. AMe, KS, AMp, PL, VKBKM, CMMB, JPFL, AMM, MT, BFM, FM, TJ and SCB are secondary authors who contributed equally to this work.

  Affiliations Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

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• Richard R. Tidwell ,

  * E-mail: tidwell@med.unc.edu

  ¶‡ CB, PDY, JLA, CAO, JB, RRT and GP are primary authors and contributed equally to this work. AMe, KS, AMp, PL, VKBKM, CMMB, JPFL, AMM, MT, BFM, FM, TJ and SCB are secondary authors who contributed equally to this work.

  Affiliation University of North Carolina, Department of Pathology and Laboratory Medicine, School of Medicine, Chapel Hill, North Carolina, United States of America

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•  [ ... ],
• Gabriele Pohlig

  ¶‡ CB, PDY, JLA, CAO, JB, RRT and GP are primary authors and contributed equally to this work. AMe, KS, AMp, PL, VKBKM, CMMB, JPFL, AMM, MT, BFM, FM, TJ and SCB are secondary authors who contributed equally to this work.

  Affiliations Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

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