Cooperation between CD4+ T Cells and Humoral Immunity Is Critical for Protection against Dengue Using a DNA Vaccine Based on the NS1 Antigen

Antônio J. S. Gonçalves; Edson R. A. Oliveira; Simone M. Costa; Marciano V. Paes; Juliana F. A. Silva; Adriana S. Azevedo; Marcio Mantuano-Barradas; Ana Cristina M. A. Nogueira; Cecília J. Almeida; Ada M. B. Alves

doi:10.1371/journal.pntd.0004277

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Open Access

Peer-reviewed

Research Article

Cooperation between CD4+ T Cells and Humoral Immunity Is Critical for Protection against Dengue Using a DNA Vaccine Based on the NS1 Antigen

Antônio J. S. Gonçalves,

Affiliation Laboratory of Biotechnology and Physiology of Viral Infections, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
⨯
Edson R. A. Oliveira,

Affiliation Laboratory of Biotechnology and Physiology of Viral Infections, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
⨯
Simone M. Costa,

Affiliation Laboratory of Biotechnology and Physiology of Viral Infections, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
⨯
Marciano V. Paes,

Affiliation Laboratory of Biotechnology and Physiology of Viral Infections, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
⨯
Juliana F. A. Silva,

Affiliation Laboratory of Biotechnology and Physiology of Viral Infections, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
⨯
Adriana S. Azevedo,

Affiliation Laboratory of Biotechnology and Physiology of Viral Infections, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
⨯
Marcio Mantuano-Barradas,

Affiliation Laboratory of Biotechnology and Physiology of Viral Infections, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
⨯
Ana Cristina M. A. Nogueira,

Affiliation Laboratory of Biotechnology and Physiology of Viral Infections, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
⨯
Cecília J. Almeida,

Affiliation Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
⨯
Ada M. B. Alves

* E-mail: ada@ioc.fiocruz.br

Affiliation Laboratory of Biotechnology and Physiology of Viral Infections, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
⨯

Cooperation between CD4+ T Cells and Humoral Immunity Is Critical for Protection against Dengue Using a DNA Vaccine Based on the NS1 Antigen

Antônio J. S. Gonçalves,
Edson R. A. Oliveira,
Simone M. Costa,
Marciano V. Paes,
Juliana F. A. Silva,
Adriana S. Azevedo,
Marcio Mantuano-Barradas,
Ana Cristina M. A. Nogueira,
Cecília J. Almeida,
Ada M. B. Alves

Published: December 9, 2015
https://doi.org/10.1371/journal.pntd.0004277

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