Rapidly Escalating Hepcidin and Associated Serum Iron Starvation Are Features of the Acute Response to Typhoid Infection in Humans

• Thomas C. Darton,

  Affiliation Oxford Vaccine Group, Centre for Clinical Vaccinology and Tropical Medicine, Department of Paediatrics, University of Oxford, and National Institute for Health Research Oxford Biomedical Research Centre, Oxford, United Kingdom

  ⨯
• Christoph J. Blohmke,

  Affiliation Oxford Vaccine Group, Centre for Clinical Vaccinology and Tropical Medicine, Department of Paediatrics, University of Oxford, and National Institute for Health Research Oxford Biomedical Research Centre, Oxford, United Kingdom

  ⨯
• Eleni Giannoulatou,

  Affiliation Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia

  ⨯
• Claire S. Waddington,

  Affiliation Oxford Vaccine Group, Centre for Clinical Vaccinology and Tropical Medicine, Department of Paediatrics, University of Oxford, and National Institute for Health Research Oxford Biomedical Research Centre, Oxford, United Kingdom

  ⨯
• Claire Jones,

  Affiliation Oxford Vaccine Group, Centre for Clinical Vaccinology and Tropical Medicine, Department of Paediatrics, University of Oxford, and National Institute for Health Research Oxford Biomedical Research Centre, Oxford, United Kingdom

  ⨯
• Pamela Sturges,

  Affiliation Department of Biochemistry, Birmingham Heartlands Hospital, Heart of England NHS Foundation Trust, Birmingham, United Kingdom

  ⨯
• Craig Webster,

  Affiliation Department of Biochemistry, Birmingham Heartlands Hospital, Heart of England NHS Foundation Trust, Birmingham, United Kingdom

  ⨯
• Hal Drakesmith,

  Affiliations BRC Blood Theme, NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom, MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

  ⨯
• Andrew J. Pollard,

  Affiliation Oxford Vaccine Group, Centre for Clinical Vaccinology and Tropical Medicine, Department of Paediatrics, University of Oxford, and National Institute for Health Research Oxford Biomedical Research Centre, Oxford, United Kingdom

  ⨯
• Andrew E. Armitage

  * E-mail: andrew.armitage@imm.ox.ac.uk

  Affiliation MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

  ⨯