Increased Nucleosomes and Neutrophil Activation Link to Disease Progression in Patients with Scrub Typhus but Not Murine Typhus in Laos

Daniel H. Paris; Femke Stephan; Ingrid Bulder; Diana Wouters; Tom van der Poll; Paul N. Newton; Nicholas P. J. Day; Sacha Zeerleder

doi:10.1371/journal.pntd.0003990

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Open Access

Peer-reviewed

Research Article

Increased Nucleosomes and Neutrophil Activation Link to Disease Progression in Patients with Scrub Typhus but Not Murine Typhus in Laos

Daniel H. Paris ,

* E-mail: parigi@tropmedres.ac

Affiliations Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine & Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR
⨯
Femke Stephan,

Affiliation Sanquin Research, Department of Immunopathology, Amsterdam, The Netherlands
⨯
Ingrid Bulder,

Affiliation Sanquin Research, Department of Immunopathology, Amsterdam, The Netherlands
⨯
Diana Wouters,

Affiliation Sanquin Research, Department of Immunopathology, Amsterdam, The Netherlands
⨯
Tom van der Poll,

Affiliation Department of Vascular Medicine and Centre for Experimental and Molecular Medicine (CEMM), Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
⨯
Paul N. Newton,

Affiliations Centre for Tropical Medicine & Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR
⨯
Nicholas P. J. Day,

Affiliations Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine & Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
⨯
Sacha Zeerleder

Affiliations Sanquin Research, Department of Immunopathology, Amsterdam, The Netherlands, Department of Hematology, Academic Medical Centre, Amsterdam, The Netherlands
⨯

Increased Nucleosomes and Neutrophil Activation Link to Disease Progression in Patients with Scrub Typhus but Not Murine Typhus in Laos

Daniel H. Paris,
Femke Stephan,
Ingrid Bulder,
Diana Wouters,
Tom van der Poll,
Paul N. Newton,
Nicholas P. J. Day,
Sacha Zeerleder

Published: August 28, 2015
https://doi.org/10.1371/journal.pntd.0003990

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Nucleosomes
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Scrub typhus
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Blood plasma
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Typhus
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