A Cholera Conjugate Vaccine Containing O-specific Polysaccharide (OSP) of V. cholerae O1 Inaba and Recombinant Fragment of Tetanus Toxin Heavy Chain (OSP:rTTHc) Induces Serum, Memory and Lamina Proprial Responses against OSP and Is Protective in Mice

• Md. Abu Sayeed ,

  Contributed equally to this work with: Md. Abu Sayeed, Meagan Kelly Bufano, Peng Xu

  Affiliations Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Center for Vaccine Sciences, International Centre for Diarrhoeal Disease Research Bangladesh (icddr,b), Dhaka, Bangladesh

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• Meagan Kelly Bufano ,

  Contributed equally to this work with: Md. Abu Sayeed, Meagan Kelly Bufano, Peng Xu

  Affiliation Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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• Peng Xu ,

  Contributed equally to this work with: Md. Abu Sayeed, Meagan Kelly Bufano, Peng Xu

  Affiliation National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK), Laboratory of Bioorganic Chemistry (LBC), National Institutes of Health, Bethesda, Maryland, United States of America

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• Grace Eckhoff,

  Affiliation Harvard Medical School, Boston, Massachusetts, United States of America

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• Richelle C. Charles,

  Affiliations Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

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• Mohammad Murshid Alam,

  Affiliations Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Center for Vaccine Sciences, International Centre for Diarrhoeal Disease Research Bangladesh (icddr,b), Dhaka, Bangladesh

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• Tania Sultana,

  Affiliations Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Center for Vaccine Sciences, International Centre for Diarrhoeal Disease Research Bangladesh (icddr,b), Dhaka, Bangladesh

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• Md. Rasheduzzaman Rashu,

  Affiliations Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Center for Vaccine Sciences, International Centre for Diarrhoeal Disease Research Bangladesh (icddr,b), Dhaka, Bangladesh

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• Amanda Berger,

  Affiliation Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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• Geoffrey Gonzalez-Escobedo,

  Affiliation Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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• Anjali Mandlik,

  Affiliation Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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• Taufiqur Rahman Bhuiyan,

  Affiliations Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Center for Vaccine Sciences, International Centre for Diarrhoeal Disease Research Bangladesh (icddr,b), Dhaka, Bangladesh

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• Daniel T. Leung,

  Affiliations Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Division of Infectious Disease, University of Utah School of Medicine, Salt Lake City, Utah, United States of America

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• Regina C. LaRocque,

  Affiliation Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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• Jason B. Harris,

  Affiliations Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, United States of America

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• Stephen B. Calderwood,

  Affiliations Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America

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• Firdausi Qadri ,

  ¶‡ These authors are joint senior authors on this work.

  Affiliation Center for Vaccine Sciences, International Centre for Diarrhoeal Disease Research Bangladesh (icddr,b), Dhaka, Bangladesh

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• W. F. Vann ,

  ¶‡ These authors are joint senior authors on this work.

  Affiliation Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Laboratory of Bacterial Toxins, Bethesda, Maryland, United States of America

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• Pavol Kováč ,

  ¶‡ These authors are joint senior authors on this work.

  Affiliation Harvard Medical School, Boston, Massachusetts, United States of America

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•  [ ... ],
• Edward T. Ryan

  * E-mail: etryan@mgh.harvard.edu

  ¶‡ These authors are joint senior authors on this work.

  Affiliations Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston, Massachusetts, United States of America

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