Distinct Phenotypes Caused by Mutation of MSH2 in Trypanosome Insect and Mammalian Life Cycle Forms Are Associated with Parasite Adaptation to Oxidative Stress

• Viviane Grazielle-Silva ,

  Contributed equally to this work with: Viviane Grazielle-Silva, Tehseen Fatima Zeb

  Affiliations Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil, The Wellcome Trust Center for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, Scotland, United Kingdom

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• Tehseen Fatima Zeb ,

  Contributed equally to this work with: Viviane Grazielle-Silva, Tehseen Fatima Zeb

  Affiliation The Wellcome Trust Center for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, Scotland, United Kingdom

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• Jason Bolderson,

  Affiliation The Wellcome Trust Center for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, Scotland, United Kingdom

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• Priscila C. Campos,

  Affiliation Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

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• Julia B. Miranda,

  Affiliation Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

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• Ceres L. Alves,

  Affiliation Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

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• Carlos R. Machado,

  Affiliation Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

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• Richard McCulloch ,

  * E-mail: Richard.mcculloch@glasgow.ac.uk (RM); santuzat@ufmg.br (SMRT)

  ¶‡ RM and SMRT also contributed equally to this work.

  Affiliation The Wellcome Trust Center for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, Scotland, United Kingdom

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• Santuza M. R. Teixeira

  * E-mail: Richard.mcculloch@glasgow.ac.uk (RM); santuzat@ufmg.br (SMRT)

  ¶‡ RM and SMRT also contributed equally to this work.

  Affiliation Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

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