A Recombinant Vesicular Stomatitis Virus-Based Lassa Fever Vaccine Protects Guinea Pigs and Macaques against Challenge with Geographically and Genetically Distinct Lassa Viruses

David Safronetz; Chad Mire; Kyle Rosenke; Friederike Feldmann; Elaine Haddock; Thomas Geisbert; Heinz Feldmann

doi:10.1371/journal.pntd.0003736

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Peer-reviewed

Research Article

A Recombinant Vesicular Stomatitis Virus-Based Lassa Fever Vaccine Protects Guinea Pigs and Macaques against Challenge with Geographically and Genetically Distinct Lassa Viruses

David Safronetz ,

* E-mail: safronetzd@niaid.nih.gov (DS); feldmannh@niaid.nih.gov (HF)

Affiliation Laboratory of Virology, Division of Intramural Research, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
⨯
Chad Mire,

Affiliation Galveston National Laboratory and Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America
⨯
Kyle Rosenke,

Affiliation Laboratory of Virology, Division of Intramural Research, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
⨯
Friederike Feldmann,

Affiliation Rocky Mountain Veterinary Branch, Division of Intramural Research, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
⨯
Elaine Haddock,

Affiliation Laboratory of Virology, Division of Intramural Research, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
⨯
Thomas Geisbert,

Affiliation Galveston National Laboratory and Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America
⨯
Heinz Feldmann

* E-mail: safronetzd@niaid.nih.gov (DS); feldmannh@niaid.nih.gov (HF)

Affiliation Laboratory of Virology, Division of Intramural Research, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
⨯

A Recombinant Vesicular Stomatitis Virus-Based Lassa Fever Vaccine Protects Guinea Pigs and Macaques against Challenge with Geographically and Genetically Distinct Lassa Viruses

David Safronetz,
Chad Mire,
Kyle Rosenke,
Friederike Feldmann,
Elaine Haddock,
Thomas Geisbert,
Heinz Feldmann

Published: April 17, 2015
https://doi.org/10.1371/journal.pntd.0003736

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