Tissue Localization and Extracellular Matrix Degradation by PI, PII and PIII Snake Venom Metalloproteinases: Clues on the Mechanisms of Venom-Induced Hemorrhage

Cristina Herrera; Teresa Escalante; Mathieu-Benoit Voisin; Alexandra Rucavado; Diego Morazán; Jéssica Kele A. Macêdo; Juan J. Calvete; Libia Sanz; Sussan Nourshargh; José María Gutiérrez; Jay W. Fox

doi:10.1371/journal.pntd.0003731

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Peer-reviewed

Research Article

Tissue Localization and Extracellular Matrix Degradation by PI, PII and PIII Snake Venom Metalloproteinases: Clues on the Mechanisms of Venom-Induced Hemorrhage

Cristina Herrera,

Affiliations Instituto de Investigaciones Farmacéuticas, Facultad de Farmacia, Universidad de Costa Rica, San José, Costa Rica, Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica
⨯
Teresa Escalante,

Affiliation Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica
⨯
Mathieu-Benoit Voisin,

Affiliation William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
⨯
Alexandra Rucavado,

Affiliation Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica
⨯
Diego Morazán,

Affiliation Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica
⨯
Jéssica Kele A. Macêdo,

Affiliation University of Virginia School of Medicine, Charlottesville, Virginia, United States of America
⨯
Juan J. Calvete,

Affiliation Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Científicas, Valencia, Spain
⨯
Libia Sanz,

Affiliation Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Científicas, Valencia, Spain
⨯
Sussan Nourshargh,

Affiliation William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
⨯
José María Gutiérrez ,

* E-mail: jose.gutiérrez@ucr.ac.cr (JMG); jwf8x@virginia.edu (JWF)

Affiliation Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica
⨯
Jay W. Fox

* E-mail: jose.gutiérrez@ucr.ac.cr (JMG); jwf8x@virginia.edu (JWF)

Affiliation University of Virginia School of Medicine, Charlottesville, Virginia, United States of America
⨯

Tissue Localization and Extracellular Matrix Degradation by PI, PII and PIII Snake Venom Metalloproteinases: Clues on the Mechanisms of Venom-Induced Hemorrhage

Cristina Herrera,
Teresa Escalante,
Mathieu-Benoit Voisin,
Alexandra Rucavado,
Diego Morazán,
Jéssica Kele A. Macêdo,
Juan J. Calvete,
Libia Sanz,
Sussan Nourshargh,
José María Gutiérrez

Published: April 24, 2015
https://doi.org/10.1371/journal.pntd.0003731

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Hemorrhage
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Collagens
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Venoms
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Hydrolysis
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Extracellular matrix proteins
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Basement membrane
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Serum proteins
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Membrane proteins
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