Platelet Activating Factor Contributes to Vascular Leak in Acute Dengue Infection

Chandima Jeewandara; Laksiri Gomes; N. Wickramasinghe; Danuta Gutowska-Owsiak; Dominic Waithe; S. A. Paranavitane; N. L. A. Shyamali; Graham S. Ogg; Gathsaurie Neelika Malavige

doi:10.1371/journal.pntd.0003459

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Open Access

Peer-reviewed

Research Article

Platelet Activating Factor Contributes to Vascular Leak in Acute Dengue Infection

Chandima Jeewandara,

Affiliations Centre for Dengue Research, University of Sri Jayawardanapura, Nugegoda, Sri Lanka, MRC Human Immunology Unit, NIHR Biomedical Research Centre, Weatherall Institute of Molecular Medicine, Oxford, United Kingdom
⨯
Laksiri Gomes,

Affiliation Centre for Dengue Research, University of Sri Jayawardanapura, Nugegoda, Sri Lanka
⨯
N. Wickramasinghe,

Affiliation Centre for Dengue Research, University of Sri Jayawardanapura, Nugegoda, Sri Lanka
⨯
Danuta Gutowska-Owsiak,

Affiliation MRC Human Immunology Unit, NIHR Biomedical Research Centre, Weatherall Institute of Molecular Medicine, Oxford, United Kingdom
⨯
Dominic Waithe,

Affiliation MRC Human Immunology Unit, NIHR Biomedical Research Centre, Weatherall Institute of Molecular Medicine, Oxford, United Kingdom
⨯
S. A. Paranavitane,

Affiliation Centre for Dengue Research, University of Sri Jayawardanapura, Nugegoda, Sri Lanka
⨯
N. L. A. Shyamali,

Affiliation Department of Medicine, Faculty of Medical Sciences, University of Sri Jayawardanapura, Nugegoda, Sri Lanka
⨯
Graham S. Ogg ,

¶‡ These authors have contributed equally to this work.

Affiliation MRC Human Immunology Unit, NIHR Biomedical Research Centre, Weatherall Institute of Molecular Medicine, Oxford, United Kingdom
⨯
Gathsaurie Neelika Malavige

* E-mail: gathsaurie.malavige@ndm.ox.ac.uk

¶‡ These authors have contributed equally to this work.

Affiliations Centre for Dengue Research, University of Sri Jayawardanapura, Nugegoda, Sri Lanka, MRC Human Immunology Unit, NIHR Biomedical Research Centre, Weatherall Institute of Molecular Medicine, Oxford, United Kingdom
⨯

Platelet Activating Factor Contributes to Vascular Leak in Acute Dengue Infection

Chandima Jeewandara,
Laksiri Gomes,
N. Wickramasinghe,
Danuta Gutowska-Owsiak,
Dominic Waithe,
S. A. Paranavitane,
N. L. A. Shyamali,
Graham S. Ogg,
Gathsaurie Neelika Malavige

Published: February 3, 2015
https://doi.org/10.1371/journal.pntd.0003459

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Dengue fever
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Vascular permeability
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Platelets
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Platelet activation
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Tight junctions
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Dengue virus
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Endothelial cells
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