Chemotherapy of Second Stage Human African Trypanosomiasis: Comparison between the Parenteral Diamidine DB829 and Its Oral Prodrug DB868 in Vervet Monkeys

• John K. Thuita ,

  * E-mail: thuitajk@yahoo.com, John.Thuita@KARI.org

  Affiliation Trypanosomiasis Research Centre, Kenya Agricultural Research Institute (TRC-KARI), Kikuyu, Kenya

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• Kristina K. Wolf,

  Current address: The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, United States of America

  Affiliation University of North Carolina Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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• Grace A. Murilla,

  Affiliation Trypanosomiasis Research Centre, Kenya Agricultural Research Institute (TRC-KARI), Kikuyu, Kenya

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• Arlene S. Bridges,

  Affiliation Department of Pathology and Laboratory Medicine, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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• David W. Boykin,

  Affiliation Department of Chemistry, Georgia State University, Atlanta, Georgia, United States of America

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• James N. Mutuku,

  Affiliation Trypanosomiasis Research Centre, Kenya Agricultural Research Institute (TRC-KARI), Kikuyu, Kenya

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• Qiang Liu,

  Affiliation University of North Carolina Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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• Susan K. Jones,

  Affiliation Department of Pathology and Laboratory Medicine, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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• Charles O. Gem,

  Affiliation Trypanosomiasis Research Centre, Kenya Agricultural Research Institute (TRC-KARI), Kikuyu, Kenya

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• Shelley Ching,

  Affiliation SVC Associates, Inc., Apex, North Carolina, United States of America

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• Richard R. Tidwell,

  Affiliation Department of Pathology and Laboratory Medicine, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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• Michael Z. Wang,

  Affiliation Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, Kansas, United States of America

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• Mary F. Paine,

  Current address: College of Pharmacy, Washington State University, Spokane, Washington, United States of America

  Affiliation University of North Carolina Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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• Reto Brun

  Affiliations Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

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