Schistosoma japonicum Soluble Egg Antigens Facilitate Hepatic Stellate Cell Apoptosis by Downregulating Akt Expression and Upregulating p53 and DR5 Expression

Jianxin Wang; Feifan Xu; Dandan Zhu; Yinong Duan; Jinling Chen; Xiaolei Sun; Xue He; Pan Li; Wei Sun; Jinrong Feng

doi:10.1371/journal.pntd.0003106

Loading metrics

Open Access

Peer-reviewed

Research Article

Schistosoma japonicum Soluble Egg Antigens Facilitate Hepatic Stellate Cell Apoptosis by Downregulating Akt Expression and Upregulating p53 and DR5 Expression

Jianxin Wang ,

Contributed equally to this work with: Jianxin Wang, Feifan Xu

Affiliations Laboratory Medicine Center, Affiliated Hospital of Nantong University, Nantong, Jiangsu, People's Republic of China, Department of Pathogen Biology, School of Medicine, Nantong University, Nantong, Jiangsu, People's Republic of China
⨯
Feifan Xu ,

Contributed equally to this work with: Jianxin Wang, Feifan Xu

Affiliations Laboratory Medicine Center, Affiliated Hospital of Nantong University, Nantong, Jiangsu, People's Republic of China, Department of Pathogen Biology, School of Medicine, Nantong University, Nantong, Jiangsu, People's Republic of China
⨯
Dandan Zhu,

Affiliation Department of Pathogen Biology, School of Medicine, Nantong University, Nantong, Jiangsu, People's Republic of China
⨯
Yinong Duan ,

* E-mail: yinongduan@gmail.com

Affiliations Laboratory Medicine Center, Affiliated Hospital of Nantong University, Nantong, Jiangsu, People's Republic of China, Department of Pathogen Biology, School of Medicine, Nantong University, Nantong, Jiangsu, People's Republic of China
⨯
Jinling Chen,

Affiliation Department of Pathogen Biology, School of Medicine, Nantong University, Nantong, Jiangsu, People's Republic of China
⨯
Xiaolei Sun,

Affiliation Department of Pathogen Biology, School of Medicine, Nantong University, Nantong, Jiangsu, People's Republic of China
⨯
Xue He,

Affiliation Department of Pathogen Biology, School of Medicine, Nantong University, Nantong, Jiangsu, People's Republic of China
⨯
Pan Li,

Affiliation Department of Pathogen Biology, School of Medicine, Nantong University, Nantong, Jiangsu, People's Republic of China
⨯
Wei Sun,

Affiliation Department of Pathogen Biology, School of Medicine, Nantong University, Nantong, Jiangsu, People's Republic of China
⨯
Jinrong Feng

Affiliation Department of Pathogen Biology, School of Medicine, Nantong University, Nantong, Jiangsu, People's Republic of China
⨯

Schistosoma japonicum Soluble Egg Antigens Facilitate Hepatic Stellate Cell Apoptosis by Downregulating Akt Expression and Upregulating p53 and DR5 Expression

Jianxin Wang,
Feifan Xu,
Dandan Zhu,
Yinong Duan,
Jinling Chen,
Xiaolei Sun,
Xue He,
Pan Li,
Wei Sun,
Jinrong Feng

Published: August 21, 2014
https://doi.org/10.1371/journal.pntd.0003106

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.
Fibrosis
Is the Subject Area "Fibrosis" applicable to this article?

Thanks for your feedback.
Schistosoma
Is the Subject Area "Schistosoma" applicable to this article?

Thanks for your feedback.
Small interfering RNA
Is the Subject Area "Small interfering RNA" applicable to this article?

Thanks for your feedback.
Schistosoma japonicum
Is the Subject Area "Schistosoma japonicum" applicable to this article?

Thanks for your feedback.
Cell staining
Is the Subject Area "Cell staining" applicable to this article?

Thanks for your feedback.
Liver fibrosis
Is the Subject Area "Liver fibrosis" applicable to this article?

Thanks for your feedback.