Cytokine Responses to the Anti-schistosome Vaccine Candidate Antigen Glutathione-S-transferase Vary with Host Age and Are Boosted by Praziquantel Treatment

Claire D. Bourke; Norman Nausch; Nadine Rujeni; Laura J. Appleby; François Trottein; Nicholas Midzi; Takafira Mduluza; Francisca Mutapi

doi:10.1371/journal.pntd.0002846

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Open Access

Peer-reviewed

Research Article

Cytokine Responses to the Anti-schistosome Vaccine Candidate Antigen Glutathione-S-transferase Vary with Host Age and Are Boosted by Praziquantel Treatment

Claire D. Bourke ,

* E-mail: Claire.bourke@york.ac.uk

Current address: Centre for Infection & Immunology, Department of Biology, University of York, York, United Kingdom

Affiliation Institute of Immunology & Infection Research, Centre for Immunity, Infection & Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
⨯
Norman Nausch,

Affiliation Institute of Immunology & Infection Research, Centre for Immunity, Infection & Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
⨯
Nadine Rujeni,

Affiliation Institute of Immunology & Infection Research, Centre for Immunity, Infection & Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
⨯
Laura J. Appleby,

Affiliation Institute of Immunology & Infection Research, Centre for Immunity, Infection & Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
⨯
François Trottein,

Affiliation Centre d'Infection et d'Immunité de Lille, Inserm U 1019, Institut Pasteur de Lille, Université Lille Nord de France, Lille, France
⨯
Nicholas Midzi,

Current address: University of Zimbabwe, College of Health Sciences, Department of Medical Microbiology, Avondale, Harare, Zimbabwe

Affiliation National Institute of Health Research, Harare, Zimbabwe
⨯
Takafira Mduluza,

Affiliation Biochemistry Department, University of Zimbabwe, Harare, Zimbabwe
⨯
Francisca Mutapi

Affiliation Institute of Immunology & Infection Research, Centre for Immunity, Infection & Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
⨯

Cytokine Responses to the Anti-schistosome Vaccine Candidate Antigen Glutathione-S-transferase Vary with Host Age and Are Boosted by Praziquantel Treatment

Claire D. Bourke,
Norman Nausch,
Nadine Rujeni,
Laura J. Appleby,
François Trottein,
Nicholas Midzi,
Takafira Mduluza,
Francisca Mutapi

Published: May 8, 2014
https://doi.org/10.1371/journal.pntd.0002846

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