A Thrombomodulin Mutation that Impairs Active Protein C Generation Is Detrimental in Severe Pneumonia-Derived Gram-Negative Sepsis (Melioidosis)

Liesbeth M. Kager; W. Joost Wiersinga; Joris J. T. H. Roelofs; Onno J. de Boer; Hartmut Weiler; Cornelis van 't Veer; Tom van der Poll

doi:10.1371/journal.pntd.0002819

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Open Access

Peer-reviewed

Research Article

A Thrombomodulin Mutation that Impairs Active Protein C Generation Is Detrimental in Severe Pneumonia-Derived Gram-Negative Sepsis (Melioidosis)

Liesbeth M. Kager ,

* E-mail: l.m.kager@amc.uva.nl

Affiliations Center for Experimental and Molecular Medicine, Academic Medical Center-University of Amsterdam, Amsterdam, The Netherlands, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center-University of Amsterdam, Amsterdam, The Netherlands
⨯
W. Joost Wiersinga,

Affiliations Center for Experimental and Molecular Medicine, Academic Medical Center-University of Amsterdam, Amsterdam, The Netherlands, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center-University of Amsterdam, Amsterdam, The Netherlands, Division of Infectious Diseases, Academic Medical Center-University of Amsterdam, Amsterdam, The Netherlands
⨯
Joris J. T. H. Roelofs,

Affiliation Department of Pathology, Academic Medical Center-University of Amsterdam, Amsterdam, The Netherlands
⨯
Onno J. de Boer,

Affiliation Department of Pathology, Academic Medical Center-University of Amsterdam, Amsterdam, The Netherlands
⨯
Hartmut Weiler,

Affiliation Blood Research Institute, Blood Center of Wisconsin, Milwaukee, Wisconsin, United States of America
⨯
Cornelis van 't Veer,

Affiliations Center for Experimental and Molecular Medicine, Academic Medical Center-University of Amsterdam, Amsterdam, The Netherlands, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center-University of Amsterdam, Amsterdam, The Netherlands
⨯
Tom van der Poll

Affiliations Center for Experimental and Molecular Medicine, Academic Medical Center-University of Amsterdam, Amsterdam, The Netherlands, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center-University of Amsterdam, Amsterdam, The Netherlands, Division of Infectious Diseases, Academic Medical Center-University of Amsterdam, Amsterdam, The Netherlands
⨯

A Thrombomodulin Mutation that Impairs Active Protein C Generation Is Detrimental in Severe Pneumonia-Derived Gram-Negative Sepsis (Melioidosis)

Liesbeth M. Kager,
W. Joost Wiersinga,
Joris J. T. H. Roelofs,
Onno J. de Boer,
Hartmut Weiler,
Cornelis van 't Veer,
Tom van der Poll

Published: April 24, 2014
https://doi.org/10.1371/journal.pntd.0002819

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Melioidosis
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