Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness

• Cho Yeow Koh,

  Affiliation Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

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• Jessica E. Kim,

  Affiliation Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

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• Allan B. Wetzel,

  Affiliation Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

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• Will J. de van der Schueren,

  Affiliation Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

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• Sayaka Shibata,

  Affiliations Department of Biochemistry, University of Washington, Seattle, Washington, United States of America, Department of Chemistry, University of Washington, Seattle, Washington, United States of America

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• Ranae M. Ranade,

  Affiliation Department of Medicine, University of Washington, Seattle, Washington, United States of America

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• Jiyun Liu,

  Affiliation Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

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• Zhongsheng Zhang,

  Affiliation Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

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• J. Robert Gillespie,

  Affiliation Department of Medicine, University of Washington, Seattle, Washington, United States of America

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• Frederick S. Buckner,

  Affiliation Department of Medicine, University of Washington, Seattle, Washington, United States of America

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• Christophe L. M. J. Verlinde,

  Affiliation Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

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• Erkang Fan,

  Affiliation Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

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• Wim G. J. Hol

  * E-mail: wghol@u.washington.edu

  Affiliation Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

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