Deliberate Attenuation of Chikungunya Virus by Adaptation to Heparan Sulfate-Dependent Infectivity: A Model for Rational Arboviral Vaccine Design

Christina L. Gardner; Jozef Hritz; Chengqun Sun; Dana L. Vanlandingham; Timothy Y. Song; Elodie Ghedin; Stephen Higgs; William B. Klimstra; Kate D. Ryman

doi:10.1371/journal.pntd.0002719

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Peer-reviewed

Research Article

Deliberate Attenuation of Chikungunya Virus by Adaptation to Heparan Sulfate-Dependent Infectivity: A Model for Rational Arboviral Vaccine Design

Christina L. Gardner,

Affiliations Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Microbiology & Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Jozef Hritz,

Affiliation CEITEC, Masaryk University, Brno, Czech Republic
⨯
Chengqun Sun,

Affiliations Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Microbiology & Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Dana L. Vanlandingham,

Affiliation Department of Diagnostic Medicine & Pathobiology, Biosecurity Research Institute, Kansas State University, Manhattan, Kansas, United States of America
⨯
Timothy Y. Song,

Affiliations Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Elodie Ghedin,

Affiliations Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Stephen Higgs,

Affiliation Department of Diagnostic Medicine & Pathobiology, Biosecurity Research Institute, Kansas State University, Manhattan, Kansas, United States of America
⨯
William B. Klimstra,

Affiliations Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Microbiology & Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Kate D. Ryman

* E-mail: ryman@pitt.edu

Affiliations Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Microbiology & Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯

Deliberate Attenuation of Chikungunya Virus by Adaptation to Heparan Sulfate-Dependent Infectivity: A Model for Rational Arboviral Vaccine Design

Christina L. Gardner,
Jozef Hritz,
Chengqun Sun,
Dana L. Vanlandingham,
Timothy Y. Song,
Elodie Ghedin,
Stephen Higgs,
William B. Klimstra,
Kate D. Ryman

Published: February 20, 2014
https://doi.org/10.1371/journal.pntd.0002719

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