Parasite-Antigen Driven Expansion of IL-5− and IL-5+ Th2 Human Subpopulations in Lymphatic Filariasis and Their Differential Dependence on IL-10 and TGFβ

Open Access

Peer-reviewed

Research Article

Parasite-Antigen Driven Expansion of IL-5⁻ and IL-5⁺ Th2 Human Subpopulations in Lymphatic Filariasis and Their Differential Dependence on IL-10 and TGFβ

Rajamanickam Anuradha,

Affiliation National Institutes of Health—International Center for Excellence in Research, Chennai, India
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Parakkal Jovvian George,

Affiliation National Institutes of Health—International Center for Excellence in Research, Chennai, India
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Luke E. Hanna,

Affiliation Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Vedachalam Chandrasekaran,

Affiliation National Institute for Research in Tuberculosis, Chennai, India
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P. Paul Kumaran,

Affiliation National Institute for Research in Tuberculosis, Chennai, India
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Thomas B. Nutman,

Affiliation Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Subash Babu

* E-mail: sbabu@mail.nih.gov

Affiliations National Institutes of Health—International Center for Excellence in Research, Chennai, India, Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Cytokines
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Parasitic diseases
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T helper cells
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T cells
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Helminth infections
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Eosinophils
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Neutrophils
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Cytopathology
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