Cofactor-Independent Phosphoglycerate Mutase from Nematodes Has Limited Druggability, as Revealed by Two High-Throughput Screens

Gregory J. Crowther; Michael L. Booker; Min He; Ting Li; Sylvine Raverdy; Jacopo F. Novelli; Panqing He; Natalie R. G. Dale; Amy M. Fife; Robert H. Barker Jr; Martin L. Kramer; Wesley C. Van Voorhis; Clotilde K. S. Carlow; Ming-Wei Wang

doi:10.1371/journal.pntd.0002628

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Open Access

Peer-reviewed

Research Article

Cofactor-Independent Phosphoglycerate Mutase from Nematodes Has Limited Druggability, as Revealed by Two High-Throughput Screens

Gregory J. Crowther,

Affiliation Division of Allergy & Infectious Diseases, University of Washington, Seattle, Washington, United States of America
⨯
Michael L. Booker,

Affiliation Genzyme Corporation, Waltham, Massachusetts, United States of America
⨯
Min He,

Affiliation The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
⨯
Ting Li,

Affiliation The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
⨯
Sylvine Raverdy,

Affiliation Division of Parasitology, New England Biolabs, Ipswich, Massachusetts, United States of America
⨯
Jacopo F. Novelli,

Affiliation Division of Parasitology, New England Biolabs, Ipswich, Massachusetts, United States of America
⨯
Panqing He,

Affiliation Division of Allergy & Infectious Diseases, University of Washington, Seattle, Washington, United States of America
⨯
Natalie R. G. Dale,

Affiliation Division of Allergy & Infectious Diseases, University of Washington, Seattle, Washington, United States of America
⨯
Amy M. Fife,

Affiliation Genzyme Corporation, Waltham, Massachusetts, United States of America
⨯
Robert H. Barker Jr,

Affiliation Genzyme Corporation, Waltham, Massachusetts, United States of America
⨯
Martin L. Kramer,

Affiliation Genzyme Corporation, Waltham, Massachusetts, United States of America
⨯
Wesley C. Van Voorhis,

Affiliation Division of Allergy & Infectious Diseases, University of Washington, Seattle, Washington, United States of America
⨯
Clotilde K. S. Carlow,

Affiliation Division of Parasitology, New England Biolabs, Ipswich, Massachusetts, United States of America
⨯
Ming-Wei Wang

* E-mail: wangmw@mail.shcnc.ac.cn

Affiliation The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
⨯

Cofactor-Independent Phosphoglycerate Mutase from Nematodes Has Limited Druggability, as Revealed by Two High-Throughput Screens

Gregory J. Crowther,
Michael L. Booker,
Min He,
Ting Li,
Sylvine Raverdy,
Jacopo F. Novelli,
Panqing He,
Natalie R. G. Dale,
Amy M. Fife,
Robert H. Barker Jr

Published: January 9, 2014
https://doi.org/10.1371/journal.pntd.0002628

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