Molecular Characterization of Severin from Clonorchis sinensis Excretory/Secretory Products and Its Potential Anti-apoptotic Role in Hepatocarcinoma PLC Cells

Xueqing Chen; Shan Li; Lei He; Xiaoyun Wang; Pei Liang; Wenjun Chen; Meng Bian; Mengyu Ren; Jinsi Lin; Chi Liang; Jin Xu; Zhongdao Wu; Xuerong Li; Yan Huang; Xinbing Yu

doi:10.1371/journal.pntd.0002606

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Peer-reviewed

Research Article

Molecular Characterization of Severin from Clonorchis sinensis Excretory/Secretory Products and Its Potential Anti-apoptotic Role in Hepatocarcinoma PLC Cells

Xueqing Chen ,

Contributed equally to this work with: Xueqing Chen, Shan Li

Affiliations Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People′s Republic of China, Key Laboratory of Tropical Diseases Control at Sun Yat-sen University, Ministry of Education, Guangzhou, People′s Republic of China
⨯
Shan Li ,

Contributed equally to this work with: Xueqing Chen, Shan Li

Affiliations Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People′s Republic of China, Key Laboratory of Tropical Diseases Control at Sun Yat-sen University, Ministry of Education, Guangzhou, People′s Republic of China
⨯
Lei He,

Affiliations Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People′s Republic of China, Key Laboratory of Tropical Diseases Control at Sun Yat-sen University, Ministry of Education, Guangzhou, People′s Republic of China
⨯
Xiaoyun Wang,

Affiliations Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People′s Republic of China, Key Laboratory of Tropical Diseases Control at Sun Yat-sen University, Ministry of Education, Guangzhou, People′s Republic of China
⨯
Pei Liang,

Affiliations Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People′s Republic of China, Key Laboratory of Tropical Diseases Control at Sun Yat-sen University, Ministry of Education, Guangzhou, People′s Republic of China
⨯
Wenjun Chen,

Affiliations Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People′s Republic of China, Key Laboratory of Tropical Diseases Control at Sun Yat-sen University, Ministry of Education, Guangzhou, People′s Republic of China
⨯
Meng Bian,

Affiliations Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People′s Republic of China, Key Laboratory of Tropical Diseases Control at Sun Yat-sen University, Ministry of Education, Guangzhou, People′s Republic of China
⨯
Mengyu Ren,

Affiliations Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People′s Republic of China, Key Laboratory of Tropical Diseases Control at Sun Yat-sen University, Ministry of Education, Guangzhou, People′s Republic of China
⨯
Jinsi Lin,

Affiliations Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People′s Republic of China, Key Laboratory of Tropical Diseases Control at Sun Yat-sen University, Ministry of Education, Guangzhou, People′s Republic of China
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Chi Liang,

Affiliations Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People′s Republic of China, Key Laboratory of Tropical Diseases Control at Sun Yat-sen University, Ministry of Education, Guangzhou, People′s Republic of China
⨯
Jin Xu,

Affiliations Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People′s Republic of China, Key Laboratory of Tropical Diseases Control at Sun Yat-sen University, Ministry of Education, Guangzhou, People′s Republic of China
⨯
Zhongdao Wu,

Affiliations Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People′s Republic of China, Key Laboratory of Tropical Diseases Control at Sun Yat-sen University, Ministry of Education, Guangzhou, People′s Republic of China
⨯
Xuerong Li,

Affiliations Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People′s Republic of China, Key Laboratory of Tropical Diseases Control at Sun Yat-sen University, Ministry of Education, Guangzhou, People′s Republic of China
⨯
Yan Huang ,

* E-mail: huang66@mail.sysu.edu.cn (YH); yuxb@mail.sysu.edu.cn (XY)

Affiliations Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People′s Republic of China, Key Laboratory of Tropical Diseases Control at Sun Yat-sen University, Ministry of Education, Guangzhou, People′s Republic of China
⨯
Xinbing Yu

* E-mail: huang66@mail.sysu.edu.cn (YH); yuxb@mail.sysu.edu.cn (XY)

Affiliations Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People′s Republic of China, Key Laboratory of Tropical Diseases Control at Sun Yat-sen University, Ministry of Education, Guangzhou, People′s Republic of China
⨯

Molecular Characterization of Severin from Clonorchis sinensis Excretory/Secretory Products and Its Potential Anti-apoptotic Role in Hepatocarcinoma PLC Cells

Xueqing Chen,
Shan Li,
Lei He,
Xiaoyun Wang,
Pei Liang,
Wenjun Chen,
Meng Bian,
Mengyu Ren,
Jinsi Lin,
Chi Liang

Published: December 19, 2013
https://doi.org/10.1371/journal.pntd.0002606

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