Exploring the Trypanosoma brucei Hsp83 Potential as a Target for Structure Guided Drug Design

Juan Carlos Pizarro; Tanya Hills; Guillermo Senisterra; Amy K. Wernimont; Claire Mackenzie; Neil R. Norcross; Michael A. J. Ferguson; Paul G. Wyatt; Ian H. Gilbert; Raymond Hui

doi:10.1371/journal.pntd.0002492

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Open Access

Peer-reviewed

Research Article

Exploring the Trypanosoma brucei Hsp83 Potential as a Target for Structure Guided Drug Design

Juan Carlos Pizarro ,

* E-mail: juan.pizarro@utoronto.ca

Affiliations The Structural Genomics Consortium (SGC), University of Toronto, Toronto, Ontario, Canada, Department of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, United States of America
⨯
Tanya Hills,

Affiliation The Structural Genomics Consortium (SGC), University of Toronto, Toronto, Ontario, Canada
⨯
Guillermo Senisterra,

Affiliation The Structural Genomics Consortium (SGC), University of Toronto, Toronto, Ontario, Canada
⨯
Amy K. Wernimont,

Affiliation The Structural Genomics Consortium (SGC), University of Toronto, Toronto, Ontario, Canada
⨯
Claire Mackenzie,

Affiliation Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom
⨯
Neil R. Norcross,

Affiliation Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom
⨯
Michael A. J. Ferguson,

Affiliation Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom
⨯
Paul G. Wyatt,

Affiliation Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom
⨯
Ian H. Gilbert,

Affiliation Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom
⨯
Raymond Hui

Affiliation The Structural Genomics Consortium (SGC), University of Toronto, Toronto, Ontario, Canada
⨯

Exploring the Trypanosoma brucei Hsp83 Potential as a Target for Structure Guided Drug Design

Juan Carlos Pizarro,
Tanya Hills,
Guillermo Senisterra,
Amy K. Wernimont,
Claire Mackenzie,
Neil R. Norcross,
Michael A. J. Ferguson,
Paul G. Wyatt,
Ian H. Gilbert,
Raymond Hui

Published: October 17, 2013
https://doi.org/10.1371/journal.pntd.0002492

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